ABCG2

ABCG2
Identifiers
Aliases	ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1, ATP binding cassette subfamily G member 2 (Junior blood group)
External IDs	OMIM: 603756; MGI: 1347061; HomoloGene: 55852; GeneCards: ABCG2; OMA:ABCG2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	88,231,628 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	58,672,661 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of ileum; ; endothelial cell; ; mucosa of transverse colon; ; seminal vesicula; ; duodenum; ; substantia nigra; ; internal globus pallidus; ; placenta; ; C1 segment;
	Top expressed in
	right kidney; ; proximal tubule; ; human kidney; ; ileum; ; fetal liver hematopoietic progenitor cell; ; yolk sac; ; jejunum; ; tail of embryo; ; sciatic nerve; ; human fetus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ABC-type xenobiotic transporter activity; heme transmembrane transporter activity; protein homodimerization activity; transporter activity; ATPase activity; protein binding; ATP binding; ATPase-coupled transmembrane transporter activity; cholesterol transfer activity; identical protein binding; xenobiotic transmembrane transporter activity;
Cellular component	mitochondrial membranes; membrane; mitochondrion; nucleus; plasma membrane; integral component of membrane; apical plasma membrane; receptor complex;
Biological process	urate metabolic process; cellular iron ion homeostasis; heme transport; xenobiotic transmembrane transport; xenobiotic transport; transmembrane transport; cholesterol efflux; cellular detoxification;
	Sources:Amigo / QuickGO
Orthologs
	9429
	26357
	ENSG00000118777
	ENSMUSG00000029802
	Q9UNQ0
	Q7TMS5
NM_001257386; NM_004827; NM_001348985; NM_001348986; NM_001348987;
	NM_001348988; NM_001348989
	NM_011920; NM_001355477; NM_001381925; NM_001381926; NM_001381927
NP_001244315; NP_004818; NP_001335914; NP_001335915; NP_001335916;
	NP_001335917; NP_001335918
	NP_036050; NP_001342406; NP_001368854; NP_001368855; NP_001368856
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene.^[6]^[7] ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation protein used to actively pump drugs and other compounds against their concentration gradient using the bonding and hydrolysis of ATP as the energy source.^[1]

ABCG2 forms into a homodimer to assume its active transport conformation. The dimer weighs approximately 144 kDa. The expression of this transport protein is highly conserved throughout the animal kingdom, pointing to its importance.^[8]

Substrate binding with compounds occurs in the large central cavity. ABCG2 can bind to a broad range of compounds but binds strongest to flat, polycyclic chemicals with lots of hydrophobic character.^[1]

^ ^a ^b ^c Taylor NM, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP (June 2017). "Structure of the human multidrug transporter ABCG2". Nature. 546 (7659): 504–509. Bibcode:2017Natur.546..504T. doi:10.1038/nature22345. hdl:20.500.11850/233014. PMID 28554189. S2CID 4461745.
^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118777 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029802 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Allikmets R, Gerrard B, Hutchinson A, Dean M (October 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–1655. doi:10.1093/hmg/5.10.1649. PMID 8894702.
^ Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD (December 1998). "A multidrug resistance transporter from human MCF-7 breast cancer cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (26): 15665–15670. Bibcode:1998PNAS...9515665D. doi:10.1073/pnas.95.26.15665. PMC 28101. PMID 9861027.
^ Cite error: The named reference :0 was invoked but never defined (see the help page).

[:1-1] Taylor NM, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP (June 2017). "Structure of the human multidrug transporter ABCG2". Nature. 546 (7659): 504–509. Bibcode:2017Natur.546..504T. doi:10.1038/nature22345. hdl:20.500.11850/233014. PMID 28554189. S2CID 4461745.

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000118777 – Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000029802 – Ensembl, May 2017

[4] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8894702-6] Allikmets R, Gerrard B, Hutchinson A, Dean M (October 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–1655. doi:10.1093/hmg/5.10.1649. PMID 8894702.

[pmid9861027-7] Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD (December 1998). "A multidrug resistance transporter from human MCF-7 breast cancer cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (26): 15665–15670. Bibcode:1998PNAS...9515665D. doi:10.1073/pnas.95.26.15665. PMC 28101. PMID 9861027.

[:0-8] Cite error: The named reference :0 was invoked but never defined (see the help page).

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]