ADAM8

ADAM8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DD8
Identifiers
Aliases	ADAM8, CD156, CD156a, MS2, ADAM metallopeptidase domain 8
External IDs	OMIM: 602267; MGI: 107825; HomoloGene: 74384; GeneCards: ADAM8; OMA:ADAM8 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	133,276,868 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,572,475 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; monocyte; ; bone marrow cells; ; pancreatic ductal cell; ; periodontal fiber; ; appendix; ; upper lobe of left lung; ; right lung;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; decidua; ; trachea; ; calvaria; ; tibiofemoral joint; ; lumbar spinal ganglion; ; gastrula; ; vein; ; mesenteric lymph nodes;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein self-association; peptidase activity; protein binding; metalloendopeptidase activity; hydrolase activity; cell adhesion molecule binding; calcium ion binding; serine-type endopeptidase activity; metallopeptidase activity; zinc ion binding;
Cellular component	cytoplasm; integral component of membrane; alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex; membrane; tertiary granule; integral component of plasma membrane; cell surface; specific granule; dense core granule membrane; podosome; phagolysosome; alpha9-beta1 integrin-ADAM8 complex; plasma membrane; specific granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane;
Biological process	positive regulation of inflammatory response; extracellular matrix disassembly; proteolysis; positive regulation of cellular extravasation; positive regulation of neutrophil extravasation; positive regulation of protein processing; regulation of cell-cell adhesion; positive regulation of protein secretion; inflammatory response; cellular response to hypoxia; positive regulation of T cell migration; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; positive regulation of acute inflammatory response; cell morphogenesis; positive regulation of thymocyte apoptotic process; positive regulation of bone resorption; negative regulation of neuron apoptotic process; positive regulation of fibronectin-dependent thymocyte migration; positive regulation of eosinophil migration; positive regulation of NF-kappaB transcription factor activity; leukocyte migration involved in inflammatory response; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling; positive regulation of T cell differentiation in thymus; lymphocyte chemotaxis; positive regulation of cell adhesion; angiogenesis; neutrophil degranulation; cell-cell adhesion; positive regulation of MAP kinase activity; positive regulation of innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	101
	11501
	ENSG00000151651
	ENSMUSG00000025473
	P78325
	Q05910
	NM_001109; NM_001164489; NM_001164490
	NM_001291066; NM_007403
	NP_001100; NP_001157961; NP_001157962
	NP_001277995; NP_031429
	Wikidata
View/Edit Human	View/Edit Mouse

A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151651 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025473 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (April 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics. 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482.
^ "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151651 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025473 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9126482-5] Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (April 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics. 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482.

[entrez-6] "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".

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