Acyl carrier protein

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Acyl/peptidyl carrier protein
Acyl/peptidyl carrier protein
	Streptomyces coelicolor actinorhodin polyketide synthase acyl carrier protein - PDB: 2AF8
Identifiers
Symbol	ACP-like_sf
Pfam	PF00550
Pfam clan	CL0314
InterPro	IPR036736
PROSITE	PDOC00012
CATH	1nq4
SCOP2	1nq4 / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli.^[1] In both cases, the growing chain is bound to the ACP via a thioester derived from the distal thiol of a 4'-phosphopantetheine moiety.

^ Cronan, John E. (2014). "The Chain-Flipping Mechanism of ACP (Acyl Carrier Protein)-Dependent enzymes Appears Universal". Biochemical Journal. 460 (2): 157–163. doi:10.1042/BJ20140239. PMID 24825445.

[1] Cronan, John E. (2014). "The Chain-Flipping Mechanism of ACP (Acyl Carrier Protein)-Dependent enzymes Appears Universal". Biochemical Journal. 460 (2): 157–163. doi:10.1042/BJ20140239. PMID 24825445.

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