Addressin

MADCAM1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1BQS, 1GSM, 4HBQ, 4HC1, 4HCR, 4HD9
Identifiers
Aliases	MADCAM1, MACAM1, mucosal vascular addressin cell adhesion molecule 1
External IDs	OMIM: 102670; GeneCards: MADCAM1; OMA:MADCAM1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	505,343 bp
RNA expression pattern
	Top expressed in
	gonad; ; appendix; ; mucosa of transverse colon; ; testicle; ; mucosa of sigmoid colon; ; mucosa of ileum; ; epithelium of colon; ; right hemisphere of cerebellum; ; right frontal lobe; ; spleen;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	integrin binding involved in cell-matrix adhesion;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	leukocyte tethering or rolling; heterotypic cell-cell adhesion; cell adhesion; cell-matrix adhesion; extracellular matrix organization; receptor clustering; immune response; signal transduction; regulation of immune response; positive regulation of leukocyte migration; integrin-mediated signaling pathway; positive regulation of lymphocyte migration;
	Sources:Amigo / QuickGO
Orthologs
	8174
	n/a
	ENSG00000099866
	n/a
	Q13477
	n/a
	NM_130762; NM_130760
	n/a
	NP_570116; NP_570118
	n/a
	Wikidata
View/Edit Human

Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.^[3]^[4]^[5] The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.^[3]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099866 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: mucosal vascular addressin cell adhesion molecule 1".
^ Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ (April 1996). "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". Journal of Immunology. 156 (8): 2851–7. doi:10.4049/jimmunol.156.8.2851. PMID 8609404. S2CID 24940438.
^ Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, et al. (1997). "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene". Immunogenetics. 46 (2): 111–9. doi:10.1007/s002510050249. PMID 9162097. S2CID 9453114.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099866 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: mucosal vascular addressin cell adhesion molecule 1".

[pmid8609404-4] Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ (April 1996). "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". Journal of Immunology. 156 (8): 2851–7. doi:10.4049/jimmunol.156.8.2851. PMID 8609404. S2CID 24940438.

[pmid9162097-5] Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, et al. (1997). "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene". Immunogenetics. 46 (2): 111–9. doi:10.1007/s002510050249. PMID 9162097. S2CID 9453114.

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