Anaplastic lymphoma kinase

ALK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KUP, 2KUQ, 2XB7, 2XBA, 2XP2, 2YFX, 2YHV, 2YJR, 2YJS, 2YS5, 2YT2, 3AOX, 3L9P, 3LCS, 3LCT, 4ANL, 4ANQ, 4ANS, 4CCB, 4CCU, 4CD0, 4CLI, 4CLJ, 4CMO, 4CMT, 4CMU, 4CNH, 4CTB, 4CTC, 4DCE, 4FNW, 4FNX, 4FNY, 4FNZ, 4FOB, 4FOD, 4JOA, 4MKC, 4TT7, 4Z55, 5FTO, 5AAB, 5AAA, 5J7H, 5AA9, 5IUH, 5IUI, 5IMX, 5FTQ, 5A9U, 5IUG, 5AA8, 5AAC
Identifiers
Aliases	ALK, CD246, NBLST3, anaplastic lymphoma receptor tyrosine kinase, ALK receptor tyrosine kinase, ALK (gene), ALK1
External IDs	OMIM: 105590; MGI: 103305; HomoloGene: 68387; GeneCards: ALK; OMA:ALK - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.2-p23.1 Start 29,192,774 bp[1] End 29,921,586 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E1.3|17 43.77 cM Start 72,175,967 bp[2] End 72,911,622 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm testicle ventral tegmental area superior vestibular nucleus internal globus pallidus subthalamic nucleus buccal mucosa cell Brodmann area 23 inferior ganglion of vagus nerve middle temporal gyrus Top expressed in inferior ganglion of vagus nerve external carotid artery endolymphatic sac perirhinal cortex Jacobson's organ entorhinal cortex Ileal epithelium vasculature of trunk lumbar subsegment of spinal cord choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity NF-kappaB-inducing kinase activity protein binding identical protein binding ATP binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity Cellular component integral component of membrane membrane extracellular exosome integral component of plasma membrane intracellular anatomical structure plasma membrane protein-containing complex receptor complex Biological process regulation of apoptotic process transmembrane receptor protein tyrosine kinase signaling pathway nervous system development protein phosphorylation positive regulation of NF-kappaB transcription factor activity cell population proliferation protein autophosphorylation signal transduction neuron development peptidyl-tyrosine phosphorylation NIK/NF-kappaB signaling phosphorylation brain development hippocampus development adult behavior swimming behavior regulation of cell population proliferation regulation of dopamine receptor signaling pathway response to environmental enrichment regulation of neuron differentiation positive regulation of dendrite development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 238 11682 Ensembl ENSG00000171094 ENSMUSG00000055471 UniProt Q9UM73 P97793 RefSeq (mRNA) NM_004304 NM_001353765 NM_007439 RefSeq (protein) NP_004295 NP_001340694 NP_031465 Location (UCSC) Chr 2: 29.19 – 29.92 Mb Chr 17: 72.18 – 72.91 Mb PubMed search [3] [4]
Wikidata
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Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.^[5][6]