Back Angiogenese Afrikaans تولد الأوعية Arabic Angiogeneza BS Angiogènesi Catalan Angiogeneze Czech Angiogenese German Angiogénesis Spanish رگ‌زایی Persian Angiogeneesi Finnish Angiogenèse French

Angiogenesis

Not to be confused with vasculogenesis.
Angiogenesis
Angiogenesis following vasculogenesis
Identifiers
MeSHD000096482
Anatomical terminology
3D medical animation still showing angiogenesis

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels,[1][2][3] formed in the earlier stage of vasculogenesis. Angiogenesis continues the growth of the vasculature mainly by processes of sprouting and splitting, but processes such as coalescent angiogenesis,[4] vessel elongation and vessel cooption also play a role.[2] Vasculogenesis is the embryonic formation of endothelial cells from mesoderm cell precursors,[5] and from neovascularization, although discussions are not always precise (especially in older texts). The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease.[6]

Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue. However, it is also a fundamental step in the transition of tumors from a benign state to a malignant one, leading to the use of angiogenesis inhibitors in the treatment of cancer.[7] The essential role of angiogenesis in tumor growth was first proposed in 1971 by Judah Folkman, who described tumors as "hot and bloody,"[8] illustrating that, at least for many tumor types, flush perfusion and even hyperemia are characteristic.

  1. ^ Santulli G, ed. (2013). Angiogenesis insights from a systematic overview. New York: Nova Science. ISBN 978-1-62618-114-4.
  2. ^ a b Dudley AC, Griffioen AW (August 2023). "Pathological angiogenesis: mechanisms and therapeutic strategies". Angiogenesis. 26 (3): 313–347. doi:10.1007/s10456-023-09876-7. PMC 10105163. PMID 37060495.
  3. ^ Birbrair A, Zhang T, Wang ZM, Messi ML, Olson JD, Mintz A, Delbono O (July 2014). "Type-2 pericytes participate in normal and tumoral angiogenesis". American Journal of Physiology. Cell Physiology. 307 (1): C25–C38. doi:10.1152/ajpcell.00084.2014. PMC 4080181. PMID 24788248.
  4. ^ Nitzsche B, Rong WW, Goede A, Hoffmann B, Scarpa F, Kuebler WM, et al. (February 2022). "Coalescent angiogenesis-evidence for a novel concept of vascular network maturation". Angiogenesis. 25 (1): 35–45. doi:10.1007/s10456-021-09824-3. PMC 8669669. PMID 34905124.
  5. ^ Risau W, Flamme I (1995). "Vasculogenesis". Annual Review of Cell and Developmental Biology. 11: 73–91. doi:10.1146/annurev.cb.11.110195.000445. PMID 8689573.
  6. ^ Flamme I, Frölich T, Risau W (November 1997). "Molecular mechanisms of vasculogenesis and embryonic angiogenesis". Journal of Cellular Physiology. 173 (2): 206–210. doi:10.1002/(SICI)1097-4652(199711)173:2<206::AID-JCP22>3.0.CO;2-C. PMID 9365523. S2CID 36723610.
  7. ^ Milosevic V, Edelmann RJ, Fosse JH, Östman A, Akslen LA (2022). "Molecular Phenotypes of Endothelial Cells in Malignant Tumors". In Akslen LA, Watnick RS (eds.). Biomarkers of the Tumor Microenvironment. Cham: Springer International Publishing. pp. 31–52. doi:10.1007/978-3-030-98950-7_3. ISBN 978-3-030-98950-7.
  8. ^ Penn JS (11 March 2008). Retinal and Choroidal Angiogenesis. Springer. pp. 119–. ISBN 978-1-4020-6779-2. Retrieved 26 June 2010.

Rich TVX News Network Site

Rich TVX News Network Info

© MMXXIII Rich X Search. We shall prevail. All rights reserved. Rich X Search