Angiogenesis inhibitor

An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical drugs or diet.

While angiogenesis is a critical part of wound healing and other favorable processes, certain types of angiogenesis are associated with the growth of malignant tumors. Thus angiogenesis inhibitors have been closely studied for possible cancer treatment. Angiogenesis inhibitors were once thought to have potential as a "silver bullet" treatment applicable to many types of cancer, but the limitations of anti-angiogenic therapy have been shown in practice.^[1] Currently, angiogenesis inhibitors are recognized for their improvement of cancer immunotherapy^[2]^[3] by overcoming endothelial cell anergy. Angiogenesis inhibitors are also used to effectively treat macular degeneration in the eye, and other diseases that involve a proliferation of blood vessels.^[4]^[5]^[6]

^ Hayden EC (April 2009). "Cutting off cancer's supply lines". Nature. 458 (7239): 686–7. doi:10.1038/458686b. PMID 19360048.
^ Fukumura, D., et al., Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat Rev Clin Oncol, 2018. 15(5): p. 325-340. doi: 10.1038/nrclinonc.2018.29
^ Huinen, Z., et al., Anti-angiogenic agents - overcoming tumor endothelial cell anergy and improving immunotherapy outcomes. Nat. Rev. Clin. Oncol., 2021. 18(8): p. 527-540. doi: 10.1038/s41571-021-00496-y
^ Dudley, A.C. & Griffioen, A.W., Pathological angiogenesis: mechanisms and therapeutic strategies. Angiogenesis, 2023. doi: 10.1007/s10456-023-09876-7
^ Cancer.com [homepage on the Internet]. National Cancer Institute at the National Institutes of Health; 2011 [cited 18 March 2014]. Available from: "Angiogenesis Inhibitors". Archived from the original on 2015-02-08. Retrieved 2022-05-09.
^ Ng EW, Adamis AP (June 2005). "Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration". Canadian Journal of Ophthalmology. 40 (3): 352–68. doi:10.1016/S0008-4182(05)80078-X. PMID 15947805.

[1] Hayden EC (April 2009). "Cutting off cancer's supply lines". Nature. 458 (7239): 686–7. doi:10.1038/458686b. PMID 19360048.

[2] Fukumura, D., et al., Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat Rev Clin Oncol, 2018. 15(5): p. 325-340. doi: 10.1038/nrclinonc.2018.29

[3] Huinen, Z., et al., Anti-angiogenic agents - overcoming tumor endothelial cell anergy and improving immunotherapy outcomes. Nat. Rev. Clin. Oncol., 2021. 18(8): p. 527-540. doi: 10.1038/s41571-021-00496-y

[4] Dudley, A.C. & Griffioen, A.W., Pathological angiogenesis: mechanisms and therapeutic strategies. Angiogenesis, 2023. doi: 10.1007/s10456-023-09876-7

[5] Cancer.com [homepage on the Internet]. National Cancer Institute at the National Institutes of Health; 2011 [cited 18 March 2014]. Available from: "Angiogenesis Inhibitors". Archived from the original on 2015-02-08. Retrieved 2022-05-09.

[6] Ng EW, Adamis AP (June 2005). "Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration". Canadian Journal of Ophthalmology. 40 (3): 352–68. doi:10.1016/S0008-4182(05)80078-X. PMID 15947805.

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