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Pronunciation | /ˌɛərɪˈpɪprəzoʊl/ AIR-ih-PIP-rə-zohl Abilify /əˈbɪlɪfaɪ/ ə-BIL-if-eye |
Trade names | Abilify, Aristada, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a603012 |
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Routes of administration | By mouth, intramuscular |
Drug class | Atypical antipsychotic |
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Bioavailability | 87%[4][6][7] |
Protein binding | >99%[4][6][7] |
Metabolism | Liver (mostly via CYP3A4 and 2D6[4][6][7]) |
Elimination half-life | 75 hours (active metabolite is 94 hours)[4][6][7] |
Excretion | Kidney (27%; <1% unchanged) feces (60%; 18% unchanged)[4][6][7] |
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ECHA InfoCard | 100.112.532 |
Chemical and physical data | |
Formula | C23H27Cl2N3O2 |
Molar mass | 448.39 g·mol−1 |
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Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic.[8] It is primarily used in the treatment of schizophrenia and bipolar disorder;[8] other uses include as an add-on treatment in major depressive disorder and obsessive–compulsive disorder (OCD), tic disorders, and irritability associated with autism.[8] Aripiprazole is taken by mouth or via injection into a muscle.[8] A Cochrane review found low-quality evidence of effectiveness in treating schizophrenia.[9]
Common side effects include nausea, vomiting, constipation, sleepiness, dizziness, weight gain, and akathisia.[8] Serious side effects may include neuroleptic malignant syndrome, tardive dyskinesia and anaphylaxis.[8] It is not recommended for older people with dementia-related psychosis due to an increased risk of death.[8] In pregnancy, there is evidence of possible harm to the fetus.[8][10] It is not recommended in women who are breastfeeding.[8] It has not been very well studied in people less than 18 years old.[8]
Aripiprazole was approved for medical use in the United States in 2002.[8] It is available as a generic medication.[11] In 2021, it was the 99th most commonly prescribed medication in the United States, with more than 6 million prescriptions.[12][13] It is on the World Health Organization's List of Essential Medicines.[14]
Abilify FDA label
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