| Fibrillin 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FBN1 | ||||||
| NCBI gene | 2200 | ||||||
| HGNC | 3603 | ||||||
| OMIM | 134797 | ||||||
| RefSeq | NP_000129 | ||||||
| UniProt | P35555 | ||||||
| Other data | |||||||
| Locus | Chr. 15 q21.1 | ||||||
| |||||||
Asprosin is a protein hormone produced by mammals in (white adipose) tissues that stimulates the liver to release glucose into the blood stream. Asprosin is encoded by the gene FBN1 as part of the protein profibrillin and is released from the C-terminus of the latter by specific proteolysis. In the liver, asprosin activates rapid glucose release via a cyclic adenosine monophosphate (cAMP)-dependent pathway.[1]
- ^ Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, et al. (April 2016). "Asprosin, a Fasting-Induced Glucogenic Protein Hormone". Cell. 165 (3): 566–579. doi:10.1016/j.cell.2016.02.063. PMC 4852710. PMID 27087445.
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