Atopy

Atopy
Atopy
Other names	Atopic syndrome
	Eczema—a typical atopic manifestation
Pronunciation	/ˈætəpiː/ ;
Specialty	Dermatology, immunology

Atopy is the tendency to produce an exaggerated immunoglobulin E (IgE) immune response to otherwise harmless substances in the environment.^[2] Allergic diseases are clinical manifestations of such inappropriate, atopic responses.^[2]

Atopy may have a hereditary component, although contact with the allergen or irritant must occur before the hypersensitivity reaction can develop (characteristically after re-exposure).^[3] Maternal psychological trauma in utero may also be a strong indicator for development of atopy.^[4]

The term atopy was coined by Arthur F. Coca and Robert Cooke in 1923.^[5]^[6] Many physicians and scientists use the term "atopy" for any IgE-mediated reaction (even those that are appropriate and proportional to the antigen), but many pediatricians reserve the word "atopy" for a genetically mediated predisposition to an excessive IgE reaction.^[7] The term is from Greek ἀτοπία meaning "the state of being out of place", "absurdity".^[8]

^ Merriam-Webster Dictionary: Atopy
^ ^a ^b Ralston, Stuart H., Herausgeber. Penman, Ian D., Herausgeber. Strachan, Mark W. J., Herausgeber. Hobson, Richard P., Herausgeber. Britton, Robert, Illustrator. Davidson, Leybourne S. 1894-1981 Begründer des Werks. (2018-04-23). Davidson's principles and practice of medicine. Elsevier. ISBN 978-0-7020-7028-0. OCLC 1040673074.{{cite book}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
^ "Mosby's Medical Dictionary:atopy". Archived from the original on 2011-07-10.
^ Wright, Rosalind J; Enlow, Michelle Bosquet (2008-09-01). "Maternal stress and perinatal programming in the expression of atopy". Expert Review of Clinical Immunology. 4 (5): 535–538. doi:10.1586/1744666X.4.5.535. ISSN 1744-666X. PMC 2762209. PMID 19838310.
^ Coca AF, Cooke RA. (1923) On the classification of the phenomenon of hypersensitiveness J Immunol
^ Johannes Ring; Bernhard Przybilla; Thomas Ruzicka (2006). Handbook of atopic eczema. Birkhäuser. pp. 3–. ISBN 978-3-540-23133-2. Retrieved 4 May 2010.
^ Ruby Pawankar; Stephen T. Holgate; Lanny J. Rosenwasser (7 April 2009). Allergy Frontiers: Classification and Pathomechanisms. Springer. pp. 33–. ISBN 978-4-431-88314-2. Retrieved 4 May 2010.
^ "atopy". Online Etymology Dictionary. Douglas Harper. 2019. Retrieved 26 Sep 2019.

[1] Merriam-Webster Dictionary: Atopy

[Ralston2018-2] Ralston, Stuart H., Herausgeber. Penman, Ian D., Herausgeber. Strachan, Mark W. J., Herausgeber. Hobson, Richard P., Herausgeber. Britton, Robert, Illustrator. Davidson, Leybourne S. 1894-1981 Begründer des Werks. (2018-04-23). Davidson's principles and practice of medicine. Elsevier. ISBN 978-0-7020-7028-0. OCLC 1040673074.{{cite book}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)

[urlMosby's_Medical_Dictionary:atopy-3] "Mosby's Medical Dictionary:atopy". Archived from the original on 2011-07-10.

[:0-4] Wright, Rosalind J; Enlow, Michelle Bosquet (2008-09-01). "Maternal stress and perinatal programming in the expression of atopy". Expert Review of Clinical Immunology. 4 (5): 535–538. doi:10.1586/1744666X.4.5.535. ISSN 1744-666X. PMC 2762209. PMID 19838310.

[5] Coca AF, Cooke RA. (1923) On the classification of the phenomenon of hypersensitiveness J Immunol

[RingPrzybilla2006-6] Johannes Ring; Bernhard Przybilla; Thomas Ruzicka (2006). Handbook of atopic eczema. Birkhäuser. pp. 3–. ISBN 978-3-540-23133-2. Retrieved 4 May 2010.

[PawankarHolgate2009-7] Ruby Pawankar; Stephen T. Holgate; Lanny J. Rosenwasser (7 April 2009). Allergy Frontiers: Classification and Pathomechanisms. Springer. pp. 33–. ISBN 978-4-431-88314-2. Retrieved 4 May 2010.

[8] "atopy". Online Etymology Dictionary. Douglas Harper. 2019. Retrieved 26 Sep 2019.

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