Neurodevelopmental disorder
Medical condition
Autism Other names Specialty Psychiatry (neuropsychiatry ), clinical psychology , pediatrics , occupational medicine Symptoms Difficulties in social interaction , verbal and nonverbal communication ; inflexible routines; focused interests ; repetitive body movements ; unusual sensory responses Complications Social isolation , educational and employment problems , anxiety , stress , bullying , depression , self-harm , suicidality Onset Early childhood Duration Lifelong Causes Multifactorial , with many uncertain factorsRisk factors Family history , certain genetic conditions , having older parents, certain prescribed drugs, perinatal and neonatal health issuesDiagnostic method Based on combination of clinical observation of behavior and development and comprehensive diagnostic testing completed by a team of qualified professionals. For adults, the use of a patient's written and oral history of autistic traits becomes more important Differential diagnosis Attention deficit hyperactivity disorder , intellectual disability , language disorders , social (pragmatic) communication disorder , selective mutism , stereotypic movement disorder , Rett syndrome , anxiety disorders , obsessive–compulsive disorder , schizophrenia , personality disorders Management Applied behavior analysis , cognitive behavioral therapy , occupational therapy , speech–language pathology Frequency One in 100 people (1%) worldwide[ 2] [ 3]
Autism , also known as autism spectrum disorder (ASD ),[ a] is a neurodevelopmental disorder characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing differences, focused interests , and repetitive behaviors, which may include stimming .[ 4] Formal diagnosis requires significant challenges in multiple domains of life, with characteristics that are atypical or more pronounced than expected for one's age and sociocultural context .[ 5] [ 6] [ 7] [ 8] Motor coordination difficulties are common but not required for diagnosis. Autism is a spectrum disorder , resulting in wide variations in presentation and support needs, such as that between speaking and non-speaking populations.[ 9] [ 10] [ 5] [ 6] [ 11]
Increased estimates of autism prevalence since the 1990s are primarily attributed to broader criteria and increased awareness, although a true rise in prevalence is possible.[ 12] [ 13] The World Health Organization estimates about 1 in 100 children were diagnosed between 2012 and 2021, noting an increasing trend.[ b] [ 2] [ 3] This rise has fueled anti-vaccine activists ' disproven claim that vaccines cause autism .[ 14] While precise causes are mostly unknown, research shows that autism is highly heritable and polygenic. Environmental factors play a relatively small role, mainly prenatally.[ 15] [ 16] [ 17] Boys are diagnosed significantly more often than girls .[ 18] Autism frequently co-occurs with attention deficit hyperactivity disorder (ADHD), epilepsy , and intellectual disability .[ 19] [ 20] [ 21]
There is no known cure for autism, and there are advocates who oppose pursuing one.[ 22] [ 23] [ 24] Interventions such as applied behavior analysis , speech therapy , and occupational therapy can help increase self-care, social, and language skills.[ 25] [ 26] Reducing environmental and social barriers enables autistic people to participate more fully in education , employment , and other aspects of life.[ 27] [ 28] [ 29] Medications can alleviate some co-occurring problems.[ 30] [ 31]
The view of autism as a disorder has been challenged by the neurodiversity paradigm, which frames autistic traits as a healthy variation of the human condition.[ 32] This view is supported by the autism rights movement , whose paradigm researchers have recently increasingly adopted.[ 33] [ 34] The neurodiversity framework has sparked significant debate and controversy among autistic people, advocacy groups, healthcare providers, and charities.[ 35] [ 36]
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^ a b Zeidan J, Fombonne E, Scorah J, Ibrahim A, Durkin MS, Saxena S, Yusuf A, Shih A, Elsabbagh M (15 May 2022). "Global prevalence of autism: A systematic review update" . Autism Research . 15 (5): 778– 790. doi :10.1002/aur.2696 . ISSN 1939-3806 . PMC 9310578 . PMID 35238171 .
^ a b Cite error: The named reference World Health Organization-2022
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^ Diagnostic and Statistical Manual of Mental Disorders (5th ed.). American Psychiatric Association . 2013. p. 31.
^ a b (World Health Organization: International Classification of Diseases version 11 (ICD-11)): https://icd.who.int/browse/2024-01/mms/en#437815624
^ a b "IACC Subcommittee Diagnostic Criteria - DSM-5 Planning Group" . iacc.hhs.gov . Retrieved 1 August 2024 .
^ Guidelines from the UK National Institute for Health & Care Excellence (NICE): https://www.nice.org.uk/guidance/cg170/resources/autism-spectrum-disorder-in-under-19s-support-and-management-pdf-35109745515205
^ Fuentes J, Hervás A, Howlin P, ESCAP ASD Working Party (2020). "ESCAP practice guidance for autism: a summary of evidence‑based recommendations for diagnosis and treatment" (PDF) . European Child & Adolescent Psychiatry . 30 (6): 961– 984. doi :10.1007/s00787-020-01587-4 . PMC 8140956 . PMID 32666205 .
^ Zhuang H, Liang Z, Ma G, Qureshi A, Ran X, Feng C, Liu X, Yan X, Shen L (2024). "Autism spectrum disorder: Pathogenesis, biomarker, and intervention therapy" . Medcomm . 5 (3): e497. doi :10.1002/mco2.497 . PMC 10908366 . PMID 38434761 .
^ Hong SJ, Valk SL, Di Martino A, Milham MP, Bernhardt BC (2017). "Multidimensional Neuroanatomical Subtyping of Autism Spectrum Disorder" . Cerebral Cortex (New York, NY) . 28 (10): 3578– 3588. doi :10.1093/cercor/bhx229 . PMC 7190887 . PMID 28968847 .
^ Waizbard-Bartov E, Fein D, Lord C, Amaral DG (2023). "Autism severity and its relationship to disability" . Autism Research . 16 (4): 685– 696. doi :10.1002/aur.2898 . ISSN 1939-3806 . PMC 10500663 . PMID 36786314 .
^ Wazana A, Bresnahan M, Kline J (June 2007). "The autism epidemic: fact or artifact?". Journal of the American Academy of Child and Adolescent Psychiatry . 46 (6): 721– 730. doi :10.1097/chi.0b013e31804a7f3b . PMID 17513984 .
^ Cite error: The named reference Russell 2021
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^ DeStefano F, Shimabukuro TT (September 2019). "The MMR Vaccine and Autism" . Annual Review of Virology . 6 (1): 585– 600. doi :10.1146/annurev-virology-092818-015515 . PMC 6768751 . PMID 30986133 .
^ Hodges H, Fealko C, Soares N (February 2020). "Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation" . Translational Pediatrics . 9 (Suppl 1): S55–S5S65. doi :10.21037/tp.2019.09.09 . ISSN 2224-4344 . PMC 7082249 . PMID 32206584 .
^ Ratajczak HV (1 March 2011). "Theoretical aspects of autism: Causes—A review" . Journal of Immunotoxicology . 8 (1): 68– 79. doi :10.3109/1547691X.2010.545086 . ISSN 1547-691X . PMID 21299355 .
^ Mandy W, Lai MC (March 2016). "Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition" . Journal of Child Psychology and Psychiatry, and Allied Disciplines . 57 (3): 271– 292. doi :10.1111/jcpp.12501 . eISSN 1469-7610 . ISSN 0021-9630 . OCLC 01307942 . PMID 26782158 .
^ Maenner MJ, Shaw KA, Baio J, Washington A, Patrick M, DiRienzo M, et al. (March 2020). "Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016" . MMWR. Surveillance Summaries . 69 (4): 1– 12. doi :10.15585/mmwr.ss6904a1 . PMC 7119644 . PMID 32214087 .
^ Bertelli MO, Azeem MW, Underwood L, Scattoni ML, Persico AM, Ricciardello A, Sappok T, Bergmann T, Keller R (2022), Bertelli MO, Deb S(, Munir K, Hassiotis A (eds.), "Autism Spectrum Disorder" , Textbook of Psychiatry for Intellectual Disability and Autism Spectrum Disorder , Cham: Springer International Publishing, p. 391, doi :10.1007/978-3-319-95720-3_16 , ISBN 978-3-319-95720-3 , retrieved 8 June 2022 , Persons with autism spectrum disorder and/or other neurodevelopmental problems are more likely than the general population to have transgender identity, non-heterosexual sexual orientation, and other gender non-conformities .
^ Lord C, Charman T, Havdahl A, Carbone P, Anagnostou E, Boyd B, Carr T, de Vries PJ, Dissanayake C , Divan G, et al. (2022). "The Lancet Commission on the future of care and clinical research in autism" (PDF) . The Lancet . 399 (10321): 299– 300. doi :10.1016/s0140-6736(21)01541-5 . hdl :11250/2975811 . PMID 34883054 . S2CID 244917920 – via Norwegian Institute of Public Health .
^ Graham Holmes L, Ames JL, Massolo ML, Nunez DM, Croen LA (1 April 2022). "Improving the Sexual and Reproductive Health and Health Care of Autistic People" . Pediatrics . 149 (Supplement 4). American Academy of Pediatrics : e2020049437J. doi :10.1542/peds.2020-049437J . ISSN 0031-4005 . PMID 35363286 . A substantial proportion of autistic adolescents and adults are LGBTQIA+. Autistic people are more likely to be transgender or gender nonconforming compared with non-autistic people, and findings from a recent autism registry study suggest that among autistic people able to self-report on a survey, up to 18% of men and 43% of women may be sexual minorities.
^ England NH. "NHS England » Making information and the words we use accessible" . www.england.nhs.uk . Retrieved 3 May 2025 .
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^ Eric Barnes R, McCabe H (2012). "Should we welcome a cure for autism? A survey of the arguments" . Medicine, Health Care and Philosophy . 15 (3): 255– 269. doi :10.1007/s11019-011-9339-7 . ISSN 1386-7423 . PMID 21837546 .
^ CDC (18 July 2024). "Treatment and Intervention for Autism Spectrum Disorder" . Autism Spectrum Disorder (ASD) . Retrieved 28 November 2024 .
^ Kasari C, Shire S, Shih W, Landa R, Levato L, Smith T (June 2023). "Spoken language outcomes in limited language preschoolers with autism and global developmental delay: RCT of early intervention approaches" . Autism Research . 16 (6): 1236– 1246. doi :10.1002/aur.2932 . PMC 10460274 . PMID 37070270 .
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^ "Medication Treatment for Autism" . National Institute of Child Health and Human Development . 19 April 2021. Archived from the original on 7 February 2023. Retrieved 21 February 2023 .
^ Rzepka-Migut B, Paprocka J (2020). "Efficacy and Safety of Melatonin Treatment in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder—A Review of the Literature" . Brain Sciences . 10 (4): 219. doi :10.3390/brainsci10040219 . ISSN 2076-3425 . PMC 7226342 . PMID 32272607 .
^ Kapp, Steven K. Autistic community and the neurodiversity movement: Stories from the frontline. Springer Nature, 2020.
^ Happé F, Frith U (2020). "Annual Research Review: Looking back to look forward - changes in the concept of autism and implications for future research" . Journal of Child Psychology and Psychiatry, and Allied Disciplines . 61 (3): 218– 232. doi :10.1111/jcpp.13176 . ISSN 1469-7610 . PMID 31994188 .
^ Dwyer, Patrick, et al. "Community views of neurodiversity, models of disability and autism intervention: Mixed methods reveal shared goals and key tensions." Autism (2024): 13623613241273029.
^ "Disorder or difference? Autism researchers face off over field's terminology" . www.science.org . Retrieved 3 May 2025 .
^ Rodríguez Mega E (10 May 2023). " 'I am not a broken version of normal' — autistic people argue for a stronger voice in research" . Nature . 617 (7960): 238– 241. doi :10.1038/d41586-023-01549-1 . PMID 37165246 .