Autism

Autism
Other names
SpecialtyPsychiatry (neuropsychiatry), clinical psychology, pediatrics, occupational medicine
SymptomsDifficulties in social interaction, verbal and nonverbal communication; inflexible routines; focused interests; repetitive body movements; unusual sensory responses
ComplicationsSocial isolation, educational and employment problems, anxiety, stress, bullying, depression, self-harm, suicidality
OnsetEarly childhood
DurationLifelong
CausesMultifactorial, with many uncertain factors
Risk factorsFamily history, certain genetic conditions, having older parents, certain prescribed drugs, perinatal and neonatal health issues
Diagnostic methodBased on combination of clinical observation of behavior and development and comprehensive diagnostic testing completed by a team of qualified professionals. For adults, the use of a patient's written and oral history of autistic traits becomes more important
Differential diagnosisAttention deficit hyperactivity disorder, intellectual disability, language disorders, social (pragmatic) communication disorder, selective mutism, stereotypic movement disorder, Rett syndrome, anxiety disorders, obsessive–compulsive disorder, schizophrenia, personality disorders[1]
ManagementApplied behavior analysis, cognitive behavioral therapy, occupational therapy, speech–language pathology
FrequencyOne in 100 people (1%) worldwide[2][3]

Autism, also known as autism spectrum disorder (ASD),[a] is a neurodevelopmental disorder characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing differences, focused interests, and repetitive behaviors, which may include stimming.[4] Formal diagnosis requires significant challenges in multiple domains of life, with characteristics that are atypical or more pronounced than expected for one's age and sociocultural context.[5][6][7][8] Motor coordination difficulties are common but not required for diagnosis. Autism is a spectrum disorder, resulting in wide variations in presentation and support needs, such as that between speaking and non-speaking populations.[9][10][5][6][11]

Increased estimates of autism prevalence since the 1990s are primarily attributed to broader criteria and increased awareness, although a true rise in prevalence is possible.[12][13] The World Health Organization estimates about 1 in 100 children were diagnosed between 2012 and 2021, noting an increasing trend.[b][2][3] This rise has fueled anti-vaccine activists' disproven claim that vaccines cause autism.[14] While precise causes are mostly unknown, research shows that autism is highly heritable and polygenic. Environmental factors play a relatively small role, mainly prenatally.[15][16][17] Boys are diagnosed significantly more often than girls.[18] Autism frequently co-occurs with attention deficit hyperactivity disorder (ADHD), epilepsy, and intellectual disability.[19][20][21]

There is no known cure for autism, and there are advocates who oppose pursuing one.[22][23][24] Interventions such as applied behavior analysis, speech therapy, and occupational therapy can help increase self-care, social, and language skills.[25][26] Reducing environmental and social barriers enables autistic people to participate more fully in education, employment, and other aspects of life.[27][28][29] Medications can alleviate some co-occurring problems.[30][31]

The view of autism as a disorder has been challenged by the neurodiversity paradigm, which frames autistic traits as a healthy variation of the human condition.[32] This view is supported by the autism rights movement, whose paradigm researchers have recently increasingly adopted.[33][34] The neurodiversity framework has sparked significant debate and controversy among autistic people, advocacy groups, healthcare providers, and charities.[35][36]


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  1. ^ DSM-5-TR.
  2. ^ a b Zeidan J, Fombonne E, Scorah J, Ibrahim A, Durkin MS, Saxena S, Yusuf A, Shih A, Elsabbagh M (15 May 2022). "Global prevalence of autism: A systematic review update". Autism Research. 15 (5): 778–790. doi:10.1002/aur.2696. ISSN 1939-3806. PMC 9310578. PMID 35238171.
  3. ^ a b Cite error: The named reference World Health Organization-2022 was invoked but never defined (see the help page).
  4. ^ Diagnostic and Statistical Manual of Mental Disorders (5th ed.). American Psychiatric Association. 2013. p. 31.
  5. ^ a b (World Health Organization: International Classification of Diseases version 11 (ICD-11)): https://icd.who.int/browse/2024-01/mms/en#437815624
  6. ^ a b "IACC Subcommittee Diagnostic Criteria - DSM-5 Planning Group". iacc.hhs.gov. Retrieved 1 August 2024.
  7. ^ Guidelines from the UK National Institute for Health & Care Excellence (NICE): https://www.nice.org.uk/guidance/cg170/resources/autism-spectrum-disorder-in-under-19s-support-and-management-pdf-35109745515205
  8. ^ Fuentes J, Hervás A, Howlin P, ESCAP ASD Working Party (2020). "ESCAP practice guidance for autism: a summary of evidence‑based recommendations for diagnosis and treatment" (PDF). European Child & Adolescent Psychiatry. 30 (6): 961–984. doi:10.1007/s00787-020-01587-4. PMC 8140956. PMID 32666205.
  9. ^ Zhuang H, Liang Z, Ma G, Qureshi A, Ran X, Feng C, Liu X, Yan X, Shen L (2024). "Autism spectrum disorder: Pathogenesis, biomarker, and intervention therapy". Medcomm. 5 (3): e497. doi:10.1002/mco2.497. PMC 10908366. PMID 38434761.
  10. ^ Hong SJ, Valk SL, Di Martino A, Milham MP, Bernhardt BC (2017). "Multidimensional Neuroanatomical Subtyping of Autism Spectrum Disorder". Cerebral Cortex (New York, NY). 28 (10): 3578–3588. doi:10.1093/cercor/bhx229. PMC 7190887. PMID 28968847.
  11. ^ Waizbard-Bartov E, Fein D, Lord C, Amaral DG (2023). "Autism severity and its relationship to disability". Autism Research. 16 (4): 685–696. doi:10.1002/aur.2898. ISSN 1939-3806. PMC 10500663. PMID 36786314.
  12. ^ Wazana A, Bresnahan M, Kline J (June 2007). "The autism epidemic: fact or artifact?". Journal of the American Academy of Child and Adolescent Psychiatry. 46 (6): 721–730. doi:10.1097/chi.0b013e31804a7f3b. PMID 17513984.
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  14. ^ DeStefano F, Shimabukuro TT (September 2019). "The MMR Vaccine and Autism". Annual Review of Virology. 6 (1): 585–600. doi:10.1146/annurev-virology-092818-015515. PMC 6768751. PMID 30986133.
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  17. ^ Mandy W, Lai MC (March 2016). "Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition". Journal of Child Psychology and Psychiatry, and Allied Disciplines. 57 (3): 271–292. doi:10.1111/jcpp.12501. eISSN 1469-7610. ISSN 0021-9630. OCLC 01307942. PMID 26782158.
  18. ^ Maenner MJ, Shaw KA, Baio J, Washington A, Patrick M, DiRienzo M, et al. (March 2020). "Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016". MMWR. Surveillance Summaries. 69 (4): 1–12. doi:10.15585/mmwr.ss6904a1. PMC 7119644. PMID 32214087.
  19. ^ Bertelli MO, Azeem MW, Underwood L, Scattoni ML, Persico AM, Ricciardello A, Sappok T, Bergmann T, Keller R (2022), Bertelli MO, Deb S(, Munir K, Hassiotis A (eds.), "Autism Spectrum Disorder", Textbook of Psychiatry for Intellectual Disability and Autism Spectrum Disorder, Cham: Springer International Publishing, p. 391, doi:10.1007/978-3-319-95720-3_16, ISBN 978-3-319-95720-3, retrieved 8 June 2022, Persons with autism spectrum disorder and/or other neurodevelopmental problems are more likely than the general population to have transgender identity, non-heterosexual sexual orientation, and other gender non-conformities.
  20. ^ Lord C, Charman T, Havdahl A, Carbone P, Anagnostou E, Boyd B, Carr T, de Vries PJ, Dissanayake C, Divan G, et al. (2022). "The Lancet Commission on the future of care and clinical research in autism" (PDF). The Lancet. 399 (10321): 299–300. doi:10.1016/s0140-6736(21)01541-5. hdl:11250/2975811. PMID 34883054. S2CID 244917920 – via Norwegian Institute of Public Health.
  21. ^ Graham Holmes L, Ames JL, Massolo ML, Nunez DM, Croen LA (1 April 2022). "Improving the Sexual and Reproductive Health and Health Care of Autistic People". Pediatrics. 149 (Supplement 4). American Academy of Pediatrics: e2020049437J. doi:10.1542/peds.2020-049437J. ISSN 0031-4005. PMID 35363286. A substantial proportion of autistic adolescents and adults are LGBTQIA+. Autistic people are more likely to be transgender or gender nonconforming compared with non-autistic people, and findings from a recent autism registry study suggest that among autistic people able to self-report on a survey, up to 18% of men and 43% of women may be sexual minorities.
  22. ^ England NH. "NHS England » Making information and the words we use accessible". www.england.nhs.uk. Retrieved 3 May 2025.
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  25. ^ CDC (18 July 2024). "Treatment and Intervention for Autism Spectrum Disorder". Autism Spectrum Disorder (ASD). Retrieved 28 November 2024.
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  34. ^ Dwyer, Patrick, et al. "Community views of neurodiversity, models of disability and autism intervention: Mixed methods reveal shared goals and key tensions." Autism (2024): 13623613241273029.
  35. ^ "Disorder or difference? Autism researchers face off over field's terminology". www.science.org. Retrieved 3 May 2025.
  36. ^ Rodríguez Mega E (10 May 2023). "'I am not a broken version of normal' — autistic people argue for a stronger voice in research". Nature. 617 (7960): 238–241. doi:10.1038/d41586-023-01549-1. PMID 37165246.

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