B-cell activating factor

TNFSF13B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JH5, 1KD7, 1KXG, 1OQD, 1OQE, 1OSG, 3V56, 4V46, 4ZCH
Identifiers
Aliases	TNFSF13B, BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4, TNLG7A, tumor necrosis factor superfamily member 13b, TNF superfamily member 13b
External IDs	OMIM: 603969; MGI: 1344376; HomoloGene: 48443; GeneCards: TNFSF13B; OMA:TNFSF13B - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	108,308,484 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	10,089,072 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; trabecular bone; ; buccal mucosa cell; ; bone marrow; ; appendix; ; germinal epithelium; ; pancreatic epithelial cell; ; granulocyte; ; decidua;
	Top expressed in
	granulocyte; ; morula; ; zygote; ; vas deferens; ; secondary oocyte; ; right lung lobe; ; intestinal villus; ; primary oocyte; ; lumbar subsegment of spinal cord; ; urethra;
	More reference expression data
	n/a
Gene ontology
Molecular function	tumor necrosis factor receptor binding; cytokine activity; signaling receptor binding; protein binding;
Cellular component	cytoplasm; integral component of membrane; perinuclear region of cytoplasm; extracellular region; plasma membrane; membrane; extracellular space;
Biological process	cell population proliferation; tumor necrosis factor-mediated signaling pathway; immune response; signal transduction; positive regulation of cell population proliferation; immune system process; regulation of immune response; T cell costimulation; B cell homeostasis; B cell costimulation; positive regulation of T cell proliferation; positive regulation of B cell proliferation; positive regulation of germinal center formation; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	10673
	24099
	ENSG00000102524
	ENSMUSG00000031497
	Q9Y275
	Q9WU72
	NM_001145645; NM_006573
	NM_033622; NM_001347309
	NP_001139117; NP_006564
	NP_001334238; NP_296371
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans is encoded by the TNFSF13B gene.^[5]^[6] BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived TNF-like molecule (CD257 antigen; cluster of differentiation 257).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102524 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031497 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shu HB, Hu WH, Johnson H (May 1999). "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens". Journal of Leukocyte Biology. 65 (5): 680–3. doi:10.1002/jlb.65.5.680. PMID 10331498. S2CID 1498303.
^ Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P, Werner-Favre C, Zubler RH, Browning JL, Tschopp J (June 1999). "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth". The Journal of Experimental Medicine. 189 (11): 1747–56. doi:10.1084/jem.189.11.1747. PMC 2193079. PMID 10359578.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102524 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031497 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10331498-5] Shu HB, Hu WH, Johnson H (May 1999). "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens". Journal of Leukocyte Biology. 65 (5): 680–3. doi:10.1002/jlb.65.5.680. PMID 10331498. S2CID 1498303.

[pmid10359578-6] Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P, Werner-Favre C, Zubler RH, Browning JL, Tschopp J (June 1999). "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth". The Journal of Experimental Medicine. 189 (11): 1747–56. doi:10.1084/jem.189.11.1747. PMC 2193079. PMID 10359578.

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