B3GAT1

B3GAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V82, 1V83, 1V84
Identifiers
Aliases	B3GAT1, CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1, beta-1,3-glucuronyltransferase 1
External IDs	OMIM: 151290; MGI: 1924148; HomoloGene: 49551; GeneCards: B3GAT1; OMA:B3GAT1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	134,412,242 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	26,674,397 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right frontal lobe; ; amygdala; ; anterior cingulate cortex; ; prefrontal cortex; ; Brodmann area 9; ; hippocampus proper; ; putamen; ; nucleus accumbens; ; Region I of hippocampus proper;
	Top expressed in
	habenula; ; visual cortex; ; primary visual cortex; ; piriform cortex; ; superior frontal gyrus; ; subiculum; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; lateral septal nucleus; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; metal ion binding; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; extracellular region; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; Golgi membrane;
Biological process	glycosaminoglycan metabolic process; protein glycosylation; chondroitin sulfate proteoglycan biosynthetic process; chondroitin sulfate metabolic process; carbohydrate metabolic process; cellular response to hypoxia;
	Sources:Amigo / QuickGO
Orthologs
	27087
	76898
	ENSG00000109956
	ENSMUSG00000045994
	Q9P2W7
	Q9CW73
	NM_018644; NM_054025; NM_001367973
	NM_029792; NM_001310766
	NP_061114; NP_473366; NP_001354902
	NP_001297695; NP_084068
	Wikidata
View/Edit Human	View/Edit Mouse

3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins.^[5] In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. It is expressed as a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109956 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045994 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)".
^ Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T (April 2000). "Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope". Genomics. 65 (2): 166–173. doi:10.1006/geno.2000.6152. PMID 10783264.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109956 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045994 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)".

[pmid10783264-6] Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T (April 2000). "Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope". Genomics. 65 (2): 166–173. doi:10.1006/geno.2000.6152. PMID 10783264.

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