BTLA

BTLA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AW2
Identifiers
Aliases	BTLA, BTLA1, CD272, B and T lymphocyte associated
External IDs	OMIM: 607925; MGI: 2658978; HomoloGene: 52233; GeneCards: BTLA; OMA:BTLA - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	112,499,472 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	45,078,033 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; testicle; ; granulocyte; ; spleen; ; bone marrow cells; ; blood; ; mucosa of transverse colon; ; gonad; ; epithelium of colon;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; blood; ; subcutaneous adipose tissue; ; submandibular gland; ; primitive streak; ; thymus; ; embryo; ; granulocyte; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor activity; protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	T cell costimulation; adaptive immune response; immune system process; immune response-regulating cell surface receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	151888
	208154
	ENSG00000186265
	ENSMUSG00000052013
	Q7Z6A9
	Q7TSA3
	NM_001085357; NM_181780
	NM_001037719; NM_177584
	NP_001078826; NP_861445
	NP_001032808; NP_808252
	Wikidata
View/Edit Human	View/Edit Mouse

B- and T-lymphocyte attenuator or BTLA (also known as cluster of differentiation 272 or CD272) is a protein that belongs to the CD28 immunoglobulin superfamily (IgSF) which is encoded by the BTLA gene located on the 3rd human chromosome.^[5]^[6] BTLA was first discovered in 2003 as an inhibitor of Th1 expansion and it became the 3rd member of the CD28 IgSF. However, its discovered ligand herpes virus entry mediator or HVEM (also known as tumour necrosis factor receptor superfamily member 14 or TNFRSF14) belongs to the tumor necrosis factor receptor superfamily (TNFRSF). This finding was surprising because until the discovery of HVEM it was believed that receptors and ligands always belong to the same family.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186265 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052013 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: BTLA B and T lymphocyte associated".
^ Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, et al. (July 2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nature Immunology. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776. S2CID 11943145.
^ Yu X, Zheng Y, Mao R, Su Z, Zhang J (2019). "BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection". Frontiers in Immunology. 10: 617. doi:10.3389/fimmu.2019.00617. PMC 6449624. PMID 30984188.
^ Pasero C, Olive D (March 2013). "Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity". Immunology Letters. 151 (1–2): 71–5. doi:10.1016/j.imlet.2013.01.008. PMID 23439006.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186265 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052013 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BTLA B and T lymphocyte associated".

[pmid12796776-6] Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, et al. (July 2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nature Immunology. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776. S2CID 11943145.

[:0-7] Yu X, Zheng Y, Mao R, Su Z, Zhang J (2019). "BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection". Frontiers in Immunology. 10: 617. doi:10.3389/fimmu.2019.00617. PMC 6449624. PMID 30984188.

[:1-8] Pasero C, Olive D (March 2013). "Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity". Immunology Letters. 151 (1–2): 71–5. doi:10.1016/j.imlet.2013.01.008. PMID 23439006.

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