Baculoviral IAP repeat-containing protein 2

BIRC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QBH, 2L9M, 3D9T, 3D9U, 3M1D, 3MUP, 3OZ1, 3T6P, 3UW4, 4EB9, 4HY4, 4HY5, 4KMN, 4LGE, 4LGU, 4MTI, 4MU7
Identifiers
Aliases	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1, baculoviral IAP repeat containing 2
External IDs	OMIM: 601712; MGI: 1197009; HomoloGene: 900; GeneCards: BIRC2; OMA:BIRC2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	102,378,670 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	7,837,065 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; secondary oocyte; ; endothelial cell; ; epithelium of nasopharynx; ; germinal epithelium; ; tibia; ; visceral pleura; ; parietal pleura; ; pancreatic ductal cell; ; ventricular zone;
	Top expressed in
	spermatocyte; ; blood; ; spermatid; ; mesenteric lymph nodes; ; spleen; ; seminiferous tubule; ; conjunctival fornix; ; pituitary gland; ; Gonadal ridge; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; metal ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; transferase activity; ubiquitin binding; chaperone binding; FBXO family protein binding; zinc ion binding; transcription coactivator activity; ubiquitin-protein transferase activity; identical protein binding; ubiquitin protein ligase activity;
Cellular component	cytosol; XY body; membrane raft; CD40 receptor complex; cytoplasmic side of plasma membrane; nucleus; cytoplasm; protein-containing complex;
Biological process	regulation of apoptotic process; regulation of nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of protein K63-linked ubiquitination; response to hypoxia; regulation of transcription, DNA-templated; regulation of innate immune response; response to organic cyclic compound; negative regulation of ripoptosome assembly involved in necroptotic process; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; placenta development; regulation of cysteine-type endopeptidase activity; regulation of RIG-I signaling pathway; regulation of tumor necrosis factor-mediated signaling pathway; tumor necrosis factor-mediated signaling pathway; regulation of reactive oxygen species metabolic process; transcription, DNA-templated; positive regulation of protein monoubiquitination; mitotic spindle assembly; cell surface receptor signaling pathway; NIK/NF-kappaB signaling; regulation of cell population proliferation; response to organonitrogen compound; positive regulation of protein K48-linked ubiquitination; response to cAMP; response to ethanol; I-kappaB kinase/NF-kappaB signaling; proteasome-mediated ubiquitin-dependent protein catabolic process; necroptosis; apoptotic process; protein deubiquitination; cellular response to tumor necrosis factor; regulation of NIK/NF-kappaB signaling; positive regulation of protein polyubiquitination; negative regulation of necroptotic process; protein polyubiquitination; regulation of toll-like receptor signaling pathway; negative regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of cell differentiation; regulation of inflammatory response; regulation of cell cycle; regulation of necroptotic process; protein heterooligomerization; positive regulation of nucleic acid-templated transcription; MyD88-independent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; positive regulation of protein ubiquitination; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	329
	11797
	ENSG00000110330
	ENSMUSG00000057367
	Q13490
	Q62210
	NM_001256166; NM_001166; NM_001256163
	NM_007465; NM_001291503
	NP_001157; NP_001243092; NP_001243095
	NP_001278432; NP_031491
	Wikidata
View/Edit Human	View/Edit Mouse

Baculoviral IAP repeat-containing protein 2 (also known as cIAP1) is a protein that in humans is encoded by the BIRC2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110330 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057367 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (February 1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes". Nature. 379 (6563): 349–53. Bibcode:1996Natur.379..349L. doi:10.1038/379349a0. PMID 8552191. S2CID 4305853.
^ Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (February 1996). "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell. 83 (7): 1243–52. doi:10.1016/0092-8674(95)90149-3. PMID 8548810.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110330 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057367 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8552191-5] Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (February 1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes". Nature. 379 (6563): 349–53. Bibcode:1996Natur.379..349L. doi:10.1038/379349a0. PMID 8552191. S2CID 4305853.

[pmid8548810-6] Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (February 1996). "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell. 83 (7): 1243–52. doi:10.1016/0092-8674(95)90149-3. PMID 8548810.

[1]

[2]

[3]

[4]

[5]

[6]