Bemegride

Bemegride
Clinical data
Trade names	Migimide, others
Other names	Methetharimide; β,β-methylethylglutarimide
AHFS/Drugs.com	International Drug Names
ATC code	R07AB05 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only);
Identifiers
	IUPAC name 4-ethyl-4-methylpiperidine-2,6-dione;
CAS Number	64-65-3 ;
PubChem CID	2310;
ChemSpider	2220 ;
UNII	57DQA39DO2;
KEGG	D01957 ;
ChEMBL	ChEMBL1214192 ;
CompTox Dashboard (EPA)	DTXSID0045250 ;
ECHA InfoCard	100.000.535
Chemical and physical data
Formula	C8H13NO2
Molar mass	155.197 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	127 °C (261 °F)
	SMILES O=C1NC(=O)CC(CC)(C1)C;
	InChI InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11) ; Key:ORRZGUBHBVWWOP-UHFFFAOYSA-N ;
	(verify)

Bemegride (trademarked as Megimide) is a central nervous system stimulant.^[1] The drug was first made in 1911.^[2] It has been used in hypnotic overdose.^[1]

As with other chemoreceptor agonists, it is a potent emetic at doses above those normally used in management of barbiturate overdose although emesis and aspiration are a concern during treatment.

It is a controlled substance in some countries.^[1]

^ ^a ^b ^c Hofmeister A (2000). "Analeptics". Ullmann's Encyclopedia of Industrial Chemistry: 1–2. doi:10.1002/14356007.a02_267. ISBN 3527306730.
^ Thole FB, Thorpe JF (1911). "LIII.—The formation and reactions of iminocompounds. Part XV. The production of imino-derivatives of piperidine leading to the formation of the ββ-disubstituted glutaric acids". Journal of the Chemical Society, Transactions. 99: 422–448. doi:10.1039/CT9119900422.

[Hof2000-1] Hofmeister A (2000). "Analeptics". Ullmann's Encyclopedia of Industrial Chemistry: 1–2. doi:10.1002/14356007.a02_267. ISBN 3527306730.

[Thole-2] Thole FB, Thorpe JF (1911). "LIII.—The formation and reactions of iminocompounds. Part XV. The production of imino-derivatives of piperidine leading to the formation of the ββ-disubstituted glutaric acids". Journal of the Chemical Society, Transactions. 99: 422–448. doi:10.1039/CT9119900422.

[1]

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