Brain natriuretic peptide 32

NPPB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N56, 1YK1
Identifiers
Aliases	NPPB, natriuretic peptide B, BNP, Iso-ANP
External IDs	OMIM: 600295; MGI: 97368; HomoloGene: 81698; GeneCards: NPPB; OMA:NPPB - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,857,464 bp[1] End 11,858,945 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E1|4 78.57 cM Start 148,070,245 bp[2] End 148,071,662 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right auricle cardiac muscle tissue of right atrium apex of heart left ventricle right ventricle vena cava nucleus accumbens myocardium of left ventricle putamen caudate nucleus Top expressed in cardiac muscle tissue of left ventricle interventricular septum atrioventricular valve atrium right ventricle endocardial cushion lumbar spinal ganglion decidua morula embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding hormone activity signaling receptor binding diuretic hormone activity hormone receptor binding Cellular component extracellular region extracellular space protein-containing complex nucleus cytoplasm Biological process blood vessel diameter maintenance protein folding regulation of signaling receptor activity negative regulation of systemic arterial blood pressure neuropeptide signaling pathway cGMP-mediated signaling regulation of blood pressure negative regulation of angiogenesis cell surface receptor signaling pathway regulation of vascular permeability receptor guanylyl cyclase signaling pathway body fluid secretion antimicrobial humoral immune response mediated by antimicrobial peptide cGMP biosynthetic process negative regulation of cell growth positive regulation of urine volume positive regulation of renal sodium excretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4879 18158 Ensembl ENSG00000120937 ENSMUSG00000029019 UniProt P16860 P40753 RefSeq (mRNA) NM_002521 NM_001287348 NM_008726 RefSeq (protein) NP_002512 NP_002512 NP_001274277 NP_032752 Location (UCSC) Chr 1: 11.86 – 11.86 Mb Chr 4: 148.07 – 148.07 Mb PubMed search [3] [4]
Wikidata
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Brain natriuretic peptide 32 (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume.^[5] BNP is one of the three natriuretic peptides, in addition to ANP and CNP.^[6]

The 32-amino acid polypeptide BNP is secreted attached to a 76–amino acid N-terminal fragment in the prohormone called NT-proBNP (BNPT), which is biologically inactive. Once released, BNP binds to and activates the atrial natriuretic factor receptor NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better targets than ANP for diagnostic blood testing.

The physiologic actions of BNP are similar to those of ANP and include decrease in systemic vascular resistance and central venous pressure as well as an increase in natriuresis. The net effect of these peptides is a decrease in blood pressure due to the decrease in systemic vascular resistance and, thus, afterload. Additionally, the actions of both BNP and ANP result in a decrease in cardiac output due to an overall decrease in central venous pressure and preload as a result of the reduction in blood volume that follows natriuresis and diuresis.^[7]