Bromazepam

Bromazepam
Clinical data
Trade names	Lexotan, Lexotanil, others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Addiction; liability	High
Routes of; administration	By mouth
ATC code	N05BA08 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Prescription only (Anlage III for higher doses); UK: Class C; US: Schedule IV;
Pharmacokinetic data
Bioavailability	84%
Protein binding	70%
Metabolism	Liver: P450
Metabolites	3-hydroxybromazepam
Elimination half-life	12–20 hours (avg. 17hr)
Excretion	Urine 69%, as metabolites
Identifiers
	IUPAC name 7-bromo-5-(pyridin-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one;
CAS Number	1812-30-2 ;
PubChem CID	2441;
DrugBank	DB01558 ;
ChemSpider	2347 ;
UNII	X015L14V0O;
KEGG	D01245 ;
ChEBI	CHEBI:31302;
ChEMBL	ChEMBL277062 ;
CompTox Dashboard (EPA)	DTXSID40171081 ;
ECHA InfoCard	100.015.748
Chemical and physical data
Formula	C14H10BrN3O
Molar mass	316.158 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1C(=O)NC2=C(C=C(C=C2)Br)C(=N1)C3=CC=CC=N3;
	InChI InChI=1S/C14H10BrN3O/c15-9-4-5-11-10(7-9)14(17-8-13(19)18-11)12-3-1-2-6-16-12/h1-7H,8H2,(H,18,19) ; Key:VMIYHDSEFNYJSL-UHFFFAOYSA-N ;
	(verify)

Bromazepam, sold under many brand names, is a benzodiazepine. It is mainly an anti-anxiety agent with similar side effects to diazepam. In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. Bromazepam typically comes in doses of 3 mg and 6 mg tablets.^[4]

It was patented in 1961 by Roche and approved for medical use in 1974.^[5]

^ ^a ^b "Bromazepam: Uses, Interactions, Mechanism of Action". DrugBank Online. Retrieved 2024-02-25.
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ "Lexotan (bromazepam) Product Insert" (PDF). Roche. 23 October 2012.
^ "Bromazepam". Pharmaceutical Benefits Scheme (PBS). Australian Government - Department of Health. Retrieved 23 March 2014.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 53X. ISBN 9783527607495.

[DrugBank-1] "Bromazepam: Uses, Interactions, Mechanism of Action". DrugBank Online. Retrieved 2024-02-25.

[2] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[3] "Lexotan (bromazepam) Product Insert" (PDF). Roche. 23 October 2012.

[B-pam-4] "Bromazepam". Pharmaceutical Benefits Scheme (PBS). Australian Government - Department of Health. Retrieved 23 March 2014.

[Fis2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 53X. ISBN 9783527607495.

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