Busulfan

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Busulfan

Clinical data
Trade names	Myleran, Busilvex, Busulfex IV
Other names	1,4-butanediol dimethanesulfonate
AHFS/Drugs.com	Monograph
MedlinePlus	a682248
License data	EU EMA: by INN US DailyMed: Busulfan US FDA: Busulfan
Pregnancy category	AU: D
Routes of administration	By mouth, intravenous
ATC code	L01AB01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: WARNING[1]Rx-only EU: Rx-only
Pharmacokinetic data
Bioavailability	60–80% (oral)
Protein binding	32.4%
Metabolism	Liver
Elimination half-life	2.5 hours
Excretion	Urine (25–60%)
Identifiers
IUPAC name Butane-1,4-diyl dimethanesulfonate
CAS Number	55-98-1 Y
PubChem CID	2478
IUPHAR/BPS	7136
DrugBank	DB01008 Y
ChemSpider	2384 Y
UNII	G1LN9045DK
KEGG	D00248 Y
ChEBI	CHEBI:28901 Y
ChEMBL	ChEMBL820 Y
CompTox Dashboard (EPA)	DTXSID3020910
ECHA InfoCard	100.000.228
Chemical and physical data
Formula	C6H14O6S2
Molar mass	246.29 g·mol−1
3D model (JSmol)	Interactive image
SMILES CS(=O)(=O)OCCCCOS(=O)(=O)C
InChI InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3 Y Key:COVZYZSDYWQREU-UHFFFAOYSA-N Y
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Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. Its chemical designation is 1,4-butanediol dimethanesulfonate.