Butalbital

Butalbital
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601009
Routes of; administration	By mouth
ATC code	none;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule III; UN: Psychotropic Schedule III;
Pharmacokinetic data
Bioavailability	20-45%
Metabolism	Liver mainly CYP3A4
Elimination half-life	35 hours
Excretion	Kidney
Identifiers
	IUPAC name 5-(2-Methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;
CAS Number	77-26-9 ;
PubChem CID	2481;
IUPHAR/BPS	7138;
DrugBank	DB00241 ;
ChemSpider	2387 ;
UNII	KHS0AZ4JVK;
KEGG	D03182 ;
ChEBI	CHEBI:102524 ;
ChEMBL	ChEMBL454 ;
CompTox Dashboard (EPA)	DTXSID6022711 ;
ECHA InfoCard	100.000.926
Chemical and physical data
Formula	C11H16N2O3
Molar mass	224.260 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1NC(=O)NC(=O)C1(CC(C)C)C\C=C;
	InChI InChI=1S/C11H16N2O3/c1-4-5-11(6-7(2)3)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16) ; Key:UZVHFVZFNXBMQJ-UHFFFAOYSA-N ;
	(verify)

Butalbital is a barbiturate with an intermediate duration of action. Butalbital is often combined with other medications, such as paracetamol (acetaminophen) (as Butalbital/acetaminophen) or aspirin, for the treatment of pain and headache. The various formulations combined with codeine are FDA-approved for the treatment of tension headaches. Butalbital has the same chemical formula as talbutal but a different structure—one that presents as 5-allyl-5-isobutylbarbituric acid.^[3]

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ "Butalbital and Acetaminophen - FDA prescribing information, side effects and uses". drugs.com. Archived from the original on 2018-01-21.
^ DE Patent 526854

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] "Butalbital and Acetaminophen - FDA prescribing information, side effects and uses". drugs.com. Archived from the original on 2018-01-21.

[3] DE Patent 526854

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