CCR1

CCR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y5D
Identifiers
Aliases	CCR1, CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, C-C motif chemokine receptor 1
External IDs	OMIM: 601159; MGI: 104618; HomoloGene: 20344; GeneCards: CCR1; OMA:CCR1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	46,208,313 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,768,729 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; periodontal fiber; ; buccal mucosa cell; ; appendix; ; spleen; ; decidua; ; bone marrow; ; trabecular bone;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; tibiofemoral joint; ; blood; ; ankle; ; body of femur; ; spleen; ; ankle joint; ; lumbar subsegment of spinal cord; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	C-C chemokine binding; G protein-coupled receptor activity; chemokine (C-C motif) ligand 5 binding; signal transducer activity; chemokine (C-C motif) ligand 7 binding; protein binding; chemokine receptor activity; C-C chemokine receptor activity; phosphatidylinositol phospholipase C activity; chemokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; external side of plasma membrane; cytoplasm;
Biological process	negative regulation of bone mineralization; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; chemokine-mediated signaling pathway; cell-cell signaling; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; positive regulation of monocyte chemotaxis; cellular calcium ion homeostasis; positive regulation of osteoclast differentiation; dendritic cell chemotaxis; negative regulation of gene expression; chemotaxis; cell surface receptor signaling pathway; cell adhesion; response to wounding; immune response; positive regulation of ERK1 and ERK2 cascade; inflammatory response; calcium ion transport; signal transduction; exocytosis; positive regulation of calcium ion transport; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	1230
	12768
	ENSG00000163823
	ENSMUSG00000025804
	P32246
	P51675
	NM_001295
	NM_009912
	NP_001286
	NP_034042
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.^[5]

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163823 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025804 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (February 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell. 72 (3): 415–25. doi:10.1016/0092-8674(93)90118-A. PMID 7679328. S2CID 38479816.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163823 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025804 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7679328-5] Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (February 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell. 72 (3): 415–25. doi:10.1016/0092-8674(93)90118-A. PMID 7679328. S2CID 38479816.

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