CCR9

CCR9
Identifiers
Aliases	CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28, C-C motif chemokine receptor 9
External IDs	OMIM: 604738; MGI: 1341902; HomoloGene: 22546; GeneCards: CCR9; OMA:CCR9 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	45,903,174 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,613,395 bp
RNA expression pattern
	Top expressed in
	thymus; ; duodenum; ; granulocyte; ; sural nerve; ; appendix; ; blood; ; bone marrow; ; spleen; ; mucosa of transverse colon; ; monocyte;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; blood; ; spleen; ; external carotid artery; ; ascending aorta; ; aortic valve; ; bone marrow; ; duodenum; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	C-C chemokine receptor activity; G protein-coupled receptor activity; signal transducer activity; chemokine receptor activity; chemokine binding; C-C chemokine binding;
Cellular component	cell surface; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; intracellular anatomical structure; external side of plasma membrane;
Biological process	positive regulation of cytosolic calcium ion concentration; chemotaxis; chemokine-mediated signaling pathway; cellular defense response; G protein-coupled receptor signaling pathway; immune response; signal transduction; CD8-positive, gamma-delta intraepithelial T cell differentiation; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	10803
	12769
	ENSG00000173585
	ENSMUSG00000029530
	P51686
	Q9WUT7
	NM_001256369; NM_006641; NM_031200; NM_001386447; NM_001386448
	NM_001166625; NM_009913
	NP_001243298; NP_006632; NP_112477
	NP_001160097; NP_034043
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene.^[5]^[6] This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.^[6]

CCR9 has also recently been designated CDw199 (cluster of differentiation w199).

The protein encoded by this gene is a member of the beta chemokine receptor family. CCR9 is a seven transmembrane protein similar to G protein-coupled receptors.^[7]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173585 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029530 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zaballos A, Gutiérrez J, Varona R, Ardavín C, Márquez G (May 1999). "Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK". Journal of Immunology. 162 (10): 5671–5675. doi:10.4049/jimmunol.162.10.5671. PMID 10229797. S2CID 21522407.
^ ^a ^b "Entrez Gene: CCR9 chemokine (C-C motif) receptor 9".
^ Schulz O, Hammerschmidt SI, Moschovakis GL, Förster R (May 2016). "Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics". Annual Review of Immunology. 34 (1): 203–242. doi:10.1146/annurev-immunol-041015-055649. PMID 26907216.
^ Griffith JW, Sokol CL, Luster AD (2014-03-21). "Chemokines and chemokine receptors: positioning cells for host defense and immunity". Annual Review of Immunology. 32 (1): 659–702. doi:10.1146/annurev-immunol-032713-120145. PMID 24655300. S2CID 10579265.
^ Tu Z, Xiao R, Xiong J, Tembo KM, Deng X, Xiong M, et al. (February 2016). "CCR9 in cancer: oncogenic role and therapeutic targeting". Journal of Hematology & Oncology. 9 (1): 10. doi:10.1186/s13045-016-0236-7. PMC 4754913. PMID 26879872.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173585 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029530 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10229797-5] Zaballos A, Gutiérrez J, Varona R, Ardavín C, Márquez G (May 1999). "Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK". Journal of Immunology. 162 (10): 5671–5675. doi:10.4049/jimmunol.162.10.5671. PMID 10229797. S2CID 21522407.

[entrez-6] "Entrez Gene: CCR9 chemokine (C-C motif) receptor 9".

[7] Schulz O, Hammerschmidt SI, Moschovakis GL, Förster R (May 2016). "Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics". Annual Review of Immunology. 34 (1): 203–242. doi:10.1146/annurev-immunol-041015-055649. PMID 26907216.

[:0-8] Griffith JW, Sokol CL, Luster AD (2014-03-21). "Chemokines and chemokine receptors: positioning cells for host defense and immunity". Annual Review of Immunology. 32 (1): 659–702. doi:10.1146/annurev-immunol-032713-120145. PMID 24655300. S2CID 10579265.

[9] Tu Z, Xiao R, Xiong J, Tembo KM, Deng X, Xiong M, et al. (February 2016). "CCR9 in cancer: oncogenic role and therapeutic targeting". Journal of Hematology & Oncology. 9 (1): 10. doi:10.1186/s13045-016-0236-7. PMC 4754913. PMID 26879872.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]