CD134

TNFRSF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D0A, 2HEV, 2HEY
Identifiers
Aliases	TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L, tumor necrosis factor receptor superfamily member 4, TNF receptor superfamily member 4
External IDs	OMIM: 600315; MGI: 104512; HomoloGene: 2496; GeneCards: TNFRSF4; OMA:TNFRSF4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.33 Start 1,211,340 bp[1] End 1,214,153 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart granulocyte gonad spleen lymph node cartilage tissue mucosa of transverse colon upper lobe of left lung blood appendix n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function virus receptor activity tumor necrosis factor-activated receptor activity protein binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane cell surface external side of plasma membrane Biological process regulation of apoptotic process tumor necrosis factor-mediated signaling pathway negative regulation of DNA-binding transcription factor activity multicellular organism development T cell proliferation response to lipopolysaccharide regulation of cell population proliferation positive regulation of B cell proliferation immune response apoptotic signaling pathway viral entry into host cell inflammatory response negative regulation of transcription, DNA-templated viral process cellular defense response regulation of protein kinase activity negative regulation of activation-induced cell death of T cells negative regulation of extrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7293 22163 Ensembl ENSG00000186827 n/a UniProt P43489 P47741 RefSeq (mRNA) NM_003327 NM_011659 RefSeq (protein) NP_003318 NP_035789 Location (UCSC) Chr 1: 1.21 – 1.21 Mb n/a PubMed search [2] [3]
Wikidata
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Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels.