CD135

FLT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RJB, 3QS7, 3QS9, 4RT7, 4XUF
Identifiers
Aliases	FLT3, CD135, FLK-2, FLK2, STK1, fms related tyrosine kinase 3, fms related receptor tyrosine kinase 3
External IDs	OMIM: 136351; MGI: 95559; HomoloGene: 3040; GeneCards: FLT3; OMA:FLT3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.2 Start 28,003,274 bp[1] End 28,100,592 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 86.88 cM|5 G3 Start 147,267,551 bp[2] End 147,337,299 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle cerebellar hemisphere monocyte right hemisphere of cerebellum bone marrow cells lymph node granulocyte body of pancreas spleen appendix Top expressed in superior olivary complex facial motor nucleus red nucleus mesenteric lymph nodes set of nuclei of trapezoid body cochlear nuclei motor neuron medial preoptic nucleus Region IV of hippocampus proper Region II of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vascular endothelial growth factor-activated receptor activity nucleotide binding protein kinase activity transferase activity protein homodimerization activity kinase activity protein binding cytokine receptor activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding protein self-association protein-containing complex binding glucocorticoid receptor binding 1-phosphatidylinositol-3-kinase activity receptor tyrosine kinase transmembrane signaling receptor activity Cellular component cytoplasm integral component of membrane cytosol endoplasmic reticulum lumen membrane integral component of plasma membrane nucleus plasma membrane endoplasmic reticulum protein-containing complex receptor complex Biological process leukocyte homeostasis regulation of apoptotic process dendritic cell differentiation cell differentiation myeloid progenitor cell differentiation positive regulation of MAP kinase activity phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway common myeloid progenitor cell proliferation positive regulation of tyrosine phosphorylation of STAT protein cellular response to cytokine stimulus positive regulation of phosphatidylinositol 3-kinase activity protein phosphorylation pro-B cell differentiation cellular response to glucocorticoid stimulus animal organ regeneration response to organonitrogen compound positive regulation of cell population proliferation lymphocyte proliferation protein autophosphorylation positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation B cell differentiation positive regulation of MAPK cascade vascular endothelial growth factor signaling pathway cytokine-mediated signaling pathway hemopoiesis MAPK cascade phosphatidylinositol-3-phosphate biosynthetic process negative regulation of signal transduction viral process negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade hematopoietic progenitor cell differentiation leukocyte differentiation lymphocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2322 14255 Ensembl ENSG00000122025 ENSMUSG00000042817 UniProt P36888 Q00342 RefSeq (mRNA) NM_004119 NM_010229 RefSeq (protein) NP_004110 NP_034359 Location (UCSC) Chr 13: 28 – 28.1 Mb Chr 5: 147.27 – 147.34 Mb PubMed search [3] [4]
Wikidata
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Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3 with fms standing for "feline McDonough sarcoma"), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. CD135 is the receptor for the cytokine Flt3 ligand (FLT3L).

It is expressed on the surface of many hematopoietic progenitor cells. Signalling of FLT3 is important for the normal development of haematopoietic stem cells and progenitor cells.

The FLT3 gene is one of the most frequently mutated genes in acute myeloid leukemia (AML).^[5] High levels of wild-type FLT3 have been reported for blast cells of some AML patients without FLT3 mutations. These high levels may be associated with worse prognosis.