CD137

TNFRSF9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D0J
Identifiers
Aliases	TNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9
External IDs	OMIM: 602250; MGI: 1101059; HomoloGene: 1199; GeneCards: TNFRSF9; OMA:TNFRSF9 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	7,943,165 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	151,030,559 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; lymph node; ; cartilage tissue; ; testicle; ; blood; ; appendix; ; white blood cell; ; monocyte; ; granulocyte; ; gallbladder;
	Top expressed in
	decidua; ; gastrula; ; blastocyst; ; thymus; ; lymph node; ; mesenteric lymph nodes; ; islet of Langerhans; ; uterus; ; morula; ; blood;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine binding; tumor necrosis factor-activated receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; external side of plasma membrane; extracellular space; plasma membrane;
Biological process	multicellular organism development; regulation of apoptotic process; response to lipopolysaccharide; inflammatory response; immune response; protein homotrimerization; apoptotic process; negative regulation of cell population proliferation; tumor necrosis factor-mediated signaling pathway; regulation of cell population proliferation; apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3604
	21942
	ENSG00000049249
	ENSMUSG00000028965
	Q07011
	P20334
	NM_001561
	NM_001077508; NM_001077509; NM_011612
	NP_001552
	NP_001070976; NP_001070977; NP_035742
	Wikidata
View/Edit Human	View/Edit Mouse

CD137, a member of the tumor necrosis factor (TNF) receptor family, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells.^[5]^[6] Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB, and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule, and as a potential target in cancer immunotherapy.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000049249 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028965 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Singh R, Kim YH, Lee SJ, Eom HS, Choi BK (Feb 2024). "4-1BB immunotherapy: advances and hurdles". Experimental & Molecular Medicine volume. 56 (1): 32–39. doi:10.1038/s12276-023-01136-4. PMC 10834507. PMID 38172595.
^ Thum E, Shao Z, Schwarz H (January 2009). "CD137, implications in immunity and potential for therapy". Frontiers in Bioscience. 14 (11): 4173–4188. doi:10.2741/3521. PMID 19273343.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000049249 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028965 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:18-5] Singh R, Kim YH, Lee SJ, Eom HS, Choi BK (Feb 2024). "4-1BB immunotherapy: advances and hurdles". Experimental & Molecular Medicine volume. 56 (1): 32–39. doi:10.1038/s12276-023-01136-4. PMC 10834507. PMID 38172595.

[:0-6] Thum E, Shao Z, Schwarz H (January 2009). "CD137, implications in immunity and potential for therapy". Frontiers in Bioscience. 14 (11): 4173–4188. doi:10.2741/3521. PMID 19273343.

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