CD146

MCAM
Identifiers
Aliases	MCAM, CD146, MUC18, melanoma cell adhesion molecule, HEMETCAM, MelCAM
External IDs	OMIM: 155735; MGI: 1933966; HomoloGene: 4742; GeneCards: MCAM; OMA:MCAM - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,321,521 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,054,024 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; right coronary artery; ; saphenous vein; ; left coronary artery; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; gastric mucosa; ; subcutaneous adipose tissue;
	Top expressed in
	tunica media of zone of aorta; ; lactiferous gland; ; left lung lobe; ; atrium; ; tunica adventitia of aorta; ; white adipose tissue; ; ascending aorta; ; belly cord; ; facial motor nucleus; ; right lung lobe;
	More reference expression data
	n/a
Orthologs
	4162
	84004
	ENSG00000076706
	ENSMUSG00000032135
	P43121
	Q8R2Y2
	NM_006500
	NM_023061; NM_001359530
	NP_006491
	NP_075548; NP_001346459
	Wikidata
View/Edit Human	View/Edit Mouse

CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076706 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032135 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kuske MD, Johnson JP (1999). "Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 87 (3–4): 258. doi:10.1159/000015439. PMID 10702685. S2CID 37508075.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076706 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032135 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10702685-5] Kuske MD, Johnson JP (1999). "Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 87 (3–4): 258. doi:10.1159/000015439. PMID 10702685. S2CID 37508075.

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