CD154

CD40LG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ALY, 1I9R, 3LKJ, 3QD6
Identifiers
Aliases	CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand
External IDs	OMIM: 300386; MGI: 88337; HomoloGene: 56; GeneCards: CD40LG; OMA:CD40LG - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3 Start 136,648,158 bp[1] End 136,660,390 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A6|X 31.21 cM Start 56,257,503 bp[2] End 56,269,402 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node blood appendix rectum spleen gallbladder mucosa of transverse colon bone marrow epithelium of colon Top expressed in thymus Meckel's cartilage spleen hip bones of pectoral girdle shoulder humerus right kidney scapula jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity CD40 receptor binding tumor necrosis factor receptor binding protein binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region external side of plasma membrane intracellular anatomical structure cell surface extracellular space Biological process leukocyte cell-cell adhesion positive regulation of interleukin-12 production negative regulation of apoptotic process tumor necrosis factor-mediated signaling pathway platelet activation positive regulation of endothelial cell apoptotic process B cell proliferation isotype switching immune response regulation of immune response B cell differentiation inflammatory response T cell costimulation positive regulation of NF-kappaB transcription factor activity positive regulation of interleukin-4 production positive regulation of interleukin-10 production positive regulation of T cell proliferation regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 959 21947 Ensembl ENSG00000102245 ENSMUSG00000031132 UniProt P29965 P27548 RefSeq (mRNA) NM_000074 NM_011616 RefSeq (protein) NP_000065 NP_035746 Location (UCSC) Chr X: 136.65 – 136.66 Mb Chr X: 56.26 – 56.27 Mb PubMed search [3] [4]
Wikidata
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CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells^[5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and integrin αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells (T_FH cells).^[6] On T_FH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication.^[7] A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome.^[8] Absence of CD154 also stops the formation of germinal centers and therefore prohibiting antibody affinity maturation, an important process in the adaptive immune system.