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CD16

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Identifiers
SymbolFCGR3A
Alt. symbolsFCGR3, FCG3
NCBI gene2214
HGNC3619
OMIM146740
RefSeqNM_000569
UniProtP08637
Other data
LocusChr. 1 q23
Search for
StructuresSwiss-model
DomainsInterPro
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Identifiers
SymbolFCGR3B
Alt. symbolsFCGR3, FCG3
NCBI gene2215
HGNC3620
OMIM610665
RefSeqNM_000570
UniProtO75015
Other data
LocusChr. 1 q23
Search for
StructuresSwiss-model
DomainsInterPro

CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells.[1][2] CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction.[3] The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily (IgSF) involved in antibody-dependent cellular cytotoxicity (ADCC).[4] It can be used to isolate populations of specific immune cells through fluorescent-activated cell sorting (FACS) or magnetic-activated cell sorting, using antibodies directed towards CD16.

  1. ^ Janeway C (2001). "Appendix II. CD antigens". Immunobiology (5 ed.). New York: Garland. ISBN 978-0-8153-3642-6.
  2. ^ Georg P, et al. (2021). "Complement activation induces excessive T cell cytotoxicity in severe COVID-19". Cell. 185 (3): 493–512.e25. doi:10.1016/j.cell.2021.12.040. PMC 8712270. PMID 35032429.
  3. ^ Vivier E, Morin P, O'Brien C, Druker B, Schlossman SF, Anderson P (January 1991). "Tyrosine phosphorylation of the Fc gamma RIII(CD16): zeta complex in human natural killer cells. Induction by antibody-dependent cytotoxicity but not by natural killing". Journal of Immunology. 146 (1): 206–10. doi:10.4049/jimmunol.146.1.206. PMID 1701792.
  4. ^ Mandelboim O, Malik P, Davis DM, Jo CH, Boyson JE, Strominger JL (May 1999). "Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity". Proceedings of the National Academy of Sciences of the United States of America. 96 (10): 5640–4. Bibcode:1999PNAS...96.5640M. doi:10.1073/pnas.96.10.5640. PMC 21913. PMID 10318937.

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