CD200

CD200
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BFI
Identifiers
Aliases	CD200, CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-200
External IDs	OMIM: 155970; MGI: 1196990; HomoloGene: 4344; GeneCards: CD200; OMA:CD200 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.2 Start 112,332,347 bp[1] End 112,362,812 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B5|16 29.53 cM Start 45,202,498 bp[2] End 45,229,416 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole ganglionic eminence Brodmann area 10 middle frontal gyrus hypothalamus orbitofrontal cortex Brodmann area 9 parietal pleura Brodmann area 46 Brodmann area 23 Top expressed in ascending aorta tunica media of zone of aorta ventral tegmental area dorsomedial hypothalamic nucleus ventromedial nucleus paraventricular nucleus of hypothalamus suprachiasmatic nucleus body of femur arcuate nucleus aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding protein binding protein homodimerization activity cell adhesion molecule binding protein binding involved in heterotypic cell-cell adhesion glycosylated region protein binding Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane cell surface axon neuron projection neuronal cell body cell body Biological process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell recognition homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of macrophage activation regulation of immune response negative regulation of leukocyte activation negative regulation of cell population proliferation negative regulation of NF-kappaB transcription factor activity positive regulation of CREB transcription factor activity heterotypic cell-cell adhesion positive regulation of transforming growth factor beta production cell-cell adhesion positive regulation of arginase activity positive regulation of protein-glutamine gamma-glutamyltransferase activity regulation of neuroinflammatory response negative regulation of neuroinflammatory response negative regulation of neuron death negative regulation of matrix metallopeptidase secretion negative regulation of macrophage migration negative regulation of T cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4345 17470 Ensembl ENSG00000091972 ENSMUSG00000022661 UniProt P41217 O54901 RefSeq (mRNA) NM_001004196 NM_001004197 NM_005944 NM_001318826 NM_001318828 NM_001318830 NM_001365851 NM_001365852 NM_001365853 NM_001365854 NM_001365855 NM_010818 NM_001358443 RefSeq (protein) NP_001004196 NP_001305755 NP_001305757 NP_001305759 NP_005935 NP_001352780 NP_001352781 NP_001352782 NP_001352783 NP_001352784 n/a Location (UCSC) Chr 3: 112.33 – 112.36 Mb Chr 16: 45.2 – 45.23 Mb PubMed search [3] [4]
Wikidata
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OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200)^[5] is a human protein encoded by the CD200 gene.^[6] CD200 gene is in human located on chromosome 3 in proximity to genes encoding other B7 proteins CD80/CD86. In mice CD200 gene is on chromosome 16.^[7]

The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two IgSF immunoglobulin domains, transmembrane region and a 19 amino acid long cytoplasmatic domain. CD 200 belongs to the immunoglobulin superfamily, particularly belongs to the B7 receptor family. ^[7][6]