CD226

CD226
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 6ISA, 6ISC, 6ISB, 6O3O
Identifiers
Aliases	CD226, DNAM-1, DNAM1, PTA1, TLiSA1, CD226 molecule
External IDs	OMIM: 605397; MGI: 3039602; HomoloGene: 4787; GeneCards: CD226; OMA:CD226 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q22.2 Start 69,831,158 bp[1] End 69,961,803 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E4 Start 89,195,091 bp[2] End 89,290,353 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood lymph node gonad testicle spleen appendix sural nerve epithelium of colon Top expressed in blood zygote spleen thymus mesenteric lymph nodes embryo bone marrow secondary oocyte subcutaneous adipose tissue esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding protein kinase binding integrin binding cell adhesion molecule binding Cellular component integral component of plasma membrane membrane raft integral component of membrane membrane cell surface external side of plasma membrane plasma membrane Biological process positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target cell adhesion regulation of immune response heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules positive regulation of Fc receptor mediated stimulatory signaling pathway cell recognition cytokine production positive regulation of immunoglobulin mediated immune response signal transduction positive regulation of natural killer cell mediated cytotoxicity positive regulation of mast cell activation positive regulation of interferon-gamma production positive regulation of natural killer cell cytokine production positive regulation of T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10666 225825 Ensembl ENSG00000150637 ENSMUSG00000034028 UniProt Q15762 Q8K4F0 RefSeq (mRNA) NM_001303618 NM_001303619 NM_006566 NM_001039148 NM_001039149 NM_178687 RefSeq (protein) NP_001290547 NP_001290548 NP_006557 NP_001034238 NP_848802 Location (UCSC) Chr 18: 69.83 – 69.96 Mb Chr 18: 89.2 – 89.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1')^[5] or DNAM-1 (DNAX Accessory Molecule-1)^[5] is a ~65 kDa  immunoglobulin-like transmembrane glycoprotein expressed on the surface of natural killer cells, NK T cell, B cells, dendritic cells, hematopoietic precursor cells, platelets, monocytes and T cells.^[6]

DNAM-1 gene CD226 is conserved between human and mice. In humans the CD226 gene is located on chromosome 18q22.3.^[7] In mice the CD226 gene is located on chromosome 18E4.