CD31

PECAM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KY5, 5C14
Identifiers
Aliases	PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet and endothelial cell adhesion molecule 1, PCAM-1
External IDs	OMIM: 173445; MGI: 97537; HomoloGene: 47925; GeneCards: PECAM1; OMA:PECAM1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	64,413,776 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,641,454 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; visceral pleura; ; lower lobe of lung; ; pericardium; ; right lung; ; parietal pleura; ; monocyte; ; upper lobe of lung; ; epithelium of colon; ; upper lobe of left lung;
	Top expressed in
	right lung lobe; ; left lung; ; left lung lobe; ; vasculature of trunk; ; mesenteric lymph nodes; ; muscle of thigh; ; ascending aorta; ; aortic valve; ; glomerular capillary; ; digastric muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity;
Cellular component	integral component of membrane; platelet alpha granule membrane; membrane raft; cell junction; plasma membrane; extracellular exosome; membrane; extracellular space; secretory granule membrane; cytoplasm; external side of plasma membrane; smooth muscle contractile fiber; cell-cell contact zone; cell periphery;
Biological process	diapedesis; glomerular endothelium development; platelet degranulation; cell adhesion; extracellular matrix organization; cell recognition; leukocyte migration; signal transduction; phagocytosis; neutrophil degranulation; leukocyte cell-cell adhesion; neutrophil extravasation; cell-cell adhesion via plasma-membrane adhesion molecules; angiogenesis; endothelial cell morphogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; Rho protein signal transduction; regulation of cell migration; monocyte extravasation; wound healing; positive regulation of tyrosine phosphorylation of STAT protein; endothelial cell migration; endothelial cell-matrix adhesion;
	Sources:Amigo / QuickGO
Orthologs
	5175
	18613
	ENSG00000261371
	ENSMUSG00000020717
	P16284
	Q08481
	NM_000442
	NM_001032378; NM_008816; NM_001305157; NM_001305158
	NP_000433
	NP_001027550; NP_001292086; NP_001292087; NP_032842
	Wikidata
View/Edit Human	View/Edit Mouse

Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3.^[5]^[6]^[7]^[8] PECAM-1 plays a key role in removing aged neutrophils from the body.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000261371 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020717 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (March 1990). "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily". Science. 247 (4947): 1219–1222. Bibcode:1990Sci...247.1219N. doi:10.1126/science.1690453. PMID 1690453.
^ Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ (June 1996). "The human PECAM1 gene maps to 17q23". Genomics. 34 (2): 229–232. doi:10.1006/geno.1996.0272. PMID 8661055.
^ Xie Y, Muller WA (October 1996). "Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1". Genomics. 37 (2): 226–228. doi:10.1006/geno.1996.0546. PMID 8921400.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000261371 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020717 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[pmid1690453-6] Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (March 1990). "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily". Science. 247 (4947): 1219–1222. Bibcode:1990Sci...247.1219N. doi:10.1126/science.1690453. PMID 1690453.

[pmid8661055-7] Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ (June 1996). "The human PECAM1 gene maps to 17q23". Genomics. 34 (2): 229–232. doi:10.1006/geno.1996.0272. PMID 8661055.

[pmid8921400-8] Xie Y, Muller WA (October 1996). "Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1". Genomics. 37 (2): 226–228. doi:10.1006/geno.1996.0546. PMID 8921400.

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