CD33

CD33
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IHB, 5J06, 5J0B, 6D48, 6D49, 6D4A, 6TL8, 7AW6
Identifiers
Aliases	CD33, CD33 molecule, SIGLEC-3, SIGLEC3, p67
External IDs	OMIM: 159590; MGI: 99440; HomoloGene: 88651; GeneCards: CD33; OMA:CD33 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,243,860 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,193,852 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; spleen; ; blood; ; bone marrow cells; ; right coronary artery; ; upper lobe of left lung; ; right lung; ; appendix; ; right adrenal cortex;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; lumbar subsegment of spinal cord; ; blood; ; tibiofemoral joint; ; gastrula; ; submandibular gland; ; calvaria; ; spleen; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; carbohydrate binding; signaling receptor activity; protein phosphatase binding; sialic acid binding;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; external side of plasma membrane; nucleus; plasma membrane; specific granule membrane; tertiary granule membrane; peroxisome; Golgi apparatus;
Biological process	cell-cell signaling; cell adhesion; signal transduction; negative regulation of cell population proliferation; regulation of immune response; neutrophil degranulation; immune response-inhibiting signal transduction; positive regulation of protein secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-8 production; negative regulation of tumor necrosis factor production; negative regulation of calcium ion transport; cell-cell adhesion; positive regulation of protein tyrosine phosphatase activity; negative regulation of monocyte activation;
	Sources:Amigo / QuickGO
Orthologs
	945
	12489
	ENSG00000105383
	ENSMUSG00000004609
	P20138
	Q63994
	NM_001082618; NM_001177608; NM_001772
	NM_001111058; NM_021293
	NP_001076087; NP_001171079; NP_001763
	NP_001104528; NP_067268
	Wikidata
View/Edit Human	View/Edit Mouse

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage.^[5] It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.^[6]

It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105383 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004609 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garnache-Ottou F, Chaperot L, Biichle S, Ferrand C, Remy-Martin JP, Deconinck E, et al. (February 2005). "Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells". Blood. 105 (3): 1256–1264. doi:10.1182/blood-2004-06-2416. PMID 15388576.
^ Hernández-Caselles T, Martínez-Esparza M, Pérez-Oliva AB, Quintanilla-Cecconi AM, García-Alonso A, Alvarez-López DM, García-Peñarrubia P (January 2006). "A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing". Journal of Leukocyte Biology. 79 (1): 46–58. doi:10.1189/jlb.0205096. PMID 16380601. S2CID 21259300.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105383 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004609 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15388576-5] Garnache-Ottou F, Chaperot L, Biichle S, Ferrand C, Remy-Martin JP, Deconinck E, et al. (February 2005). "Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells". Blood. 105 (3): 1256–1264. doi:10.1182/blood-2004-06-2416. PMID 15388576.

[pmid16380601-6] Hernández-Caselles T, Martínez-Esparza M, Pérez-Oliva AB, Quintanilla-Cecconi AM, García-Alonso A, Alvarez-López DM, García-Peñarrubia P (January 2006). "A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing". Journal of Leukocyte Biology. 79 (1): 46–58. doi:10.1189/jlb.0205096. PMID 16380601. S2CID 21259300.

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