CD34

CD34
Identifiers
Aliases	CD34, entrez:947, CD34 molecule
External IDs	OMIM: 142230; MGI: 88329; HomoloGene: 1343; GeneCards: CD34; OMA:CD34 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	207,911,402 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	194,643,587 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right auricle; ; gastric mucosa; ; subcutaneous adipose tissue; ; Descending thoracic aorta; ; left uterine tube; ; right lobe of thyroid gland; ; tibial nerve; ; body of uterus; ; right coronary artery;
	Top expressed in
	vasculature of trunk; ; efferent ductule; ; ankle; ; lip; ; left lung lobe; ; uterus; ; carotid body; ; dermis; ; cervix; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; sulfate binding; carbohydrate binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; basal plasma membrane; glomerular endothelium fenestra; apical plasma membrane; intercellular bridge; perinuclear region of cytoplasm; lysosome; external side of plasma membrane; cell periphery;
Biological process	extracellular exosome assembly; stem cell proliferation; positive regulation of interleukin-10 production; cell motility; negative regulation of blood coagulation; metanephric glomerular mesangial cell differentiation; paracrine signaling; hematopoietic stem cell proliferation; positive regulation of granulocyte colony-stimulating factor production; negative regulation of gene expression; positive regulation of angiogenesis; regulation of blood pressure; vascular wound healing; positive regulation of gene expression; glomerular filtration; negative regulation of nitric oxide biosynthetic process; cell adhesion; endothelial cell proliferation; mesangial cell-matrix adhesion; tissue homeostasis; positive regulation of vasculogenesis; endothelium development; regulation of immune response; negative regulation of cellular response to heat; positive regulation of transforming growth factor beta production; glomerular endothelium development; negative regulation of tumor necrosis factor production; cell-matrix adhesion; cell population proliferation; positive regulation of odontogenesis; negative regulation of cellular response to hypoxia; leukocyte migration; signal transduction; transdifferentiation; negative regulation of neuron death; cell-cell adhesion; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	947
	12490
	ENSG00000174059
	ENSMUSG00000016494
	P28906
	Q64314
	NM_001025109; NM_001773
	NM_001111059; NM_133654
	NP_001020280; NP_001764
	NP_001104529; NP_598415
	Wikidata
View/Edit Human	View/Edit Mouse

CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species.^[5]^[6]^[7]

CD34 derives its name from the cluster of differentiation protocol that identifies cell surface antigens. CD34 was first described on hematopoietic stem cells independently by Civin et al. and Tindle et al.^[8]^[9]^[10]^[11] as a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of hematopoietic stem cells to bone marrow extracellular matrix or directly to stromal cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to these historical and clinical associations, CD34 expression is almost ubiquitously related to hematopoietic cells; however, it is actually found on many other cell types as well.^[12]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174059 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016494 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD34 CD34 molecule".
^ Simmons DL, Satterthwaite AB, Tenen DG, Seed B (January 1992). "Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells". Journal of Immunology. 148 (1): 267–271. doi:10.4049/jimmunol.148.1.267. PMID 1370171.
^ Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG (April 1992). "Structure of the gene encoding CD34, a human hematopoietic stem cell antigen". Genomics. 12 (4): 788–794. doi:10.1016/0888-7543(92)90310-O. PMID 1374051.
^ Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH (July 1984). "Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells". Journal of Immunology. 133 (1): 157–165. doi:10.4049/jimmunol.133.1.157. PMID 6586833.
^ Tindle RW, Nichols RA, Chan L, Campana D, Catovsky D, Birnie GD (1985). "A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow". Leukemia Research. 9 (1): 1–9. doi:10.1016/0145-2126(85)90016-5. PMID 3857402.
^ Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. (1987). "BI-3C5 (CD34) defines multipotential and lineage restricted progenitor cells and their leukaemic counterparts ". In 'Leucocyte Typing 111: White Cell Differentiation Antigens. Oxford University Press, 654-655.
^ Loken M. Shah V. Civin CI.. (1987). "Characterization of myeloid antigens on human bone marrow using multicolour immunofluorescence". In: McMichael, Leucocyte Typing III:White Cell Differentiation Antigens.Oxford University Press 630-635.
^ Cite error: The named reference :0 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174059 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016494 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: CD34 CD34 molecule".

[pmid1370171-6] Simmons DL, Satterthwaite AB, Tenen DG, Seed B (January 1992). "Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells". Journal of Immunology. 148 (1): 267–271. doi:10.4049/jimmunol.148.1.267. PMID 1370171.

[pmid1374051-7] Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG (April 1992). "Structure of the gene encoding CD34, a human hematopoietic stem cell antigen". Genomics. 12 (4): 788–794. doi:10.1016/0888-7543(92)90310-O. PMID 1374051.

[8] Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH (July 1984). "Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells". Journal of Immunology. 133 (1): 157–165. doi:10.4049/jimmunol.133.1.157. PMID 6586833.

[9] Tindle RW, Nichols RA, Chan L, Campana D, Catovsky D, Birnie GD (1985). "A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow". Leukemia Research. 9 (1): 1–9. doi:10.1016/0145-2126(85)90016-5. PMID 3857402.

[10] Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. (1987). "BI-3C5 (CD34) defines multipotential and lineage restricted progenitor cells and their leukaemic counterparts ". In 'Leucocyte Typing 111: White Cell Differentiation Antigens. Oxford University Press, 654-655.

[11] Loken M. Shah V. Civin CI.. (1987). "Characterization of myeloid antigens on human bone marrow using multicolour immunofluorescence". In: McMichael, Leucocyte Typing III:White Cell Differentiation Antigens.Oxford University Press 630-635.

[:0-12] Cite error: The named reference :0 was invoked but never defined (see the help page).

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