CD36

CD36
Identifiers
Aliases	CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, CD36 molecule
External IDs	OMIM: 173510; MGI: 107899; HomoloGene: 73871; GeneCards: CD36; OMA:CD36 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.11 Start 80,369,575 bp[1] End 80,679,277 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A3|5 8.11 cM Start 17,986,688 bp[2] End 18,093,799 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in abdominal fat monocyte jejunal mucosa right ventricle subcutaneous adipose tissue myocardium of left ventricle apex of heart skin of hip right auricle vena cava Top expressed in right lung right lung lobe left lung left lung lobe tunica adventitia of aorta stroma of bone marrow intercostal muscle right ventricle right kidney digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding low-density lipoprotein particle receptor activity transforming growth factor beta binding high-density lipoprotein particle binding lipoprotein particle binding thrombospondin receptor activity lipid binding low-density lipoprotein particle binding lipoteichoic acid immune receptor activity amyloid-beta binding scavenger receptor activity Toll-like receptor binding oxidised low-density lipoprotein particle receptor activity protein-containing complex binding Cellular component Golgi apparatus apical plasma membrane phagocytic vesicle apical part of cell brush border membrane endocytic vesicle membrane integral component of plasma membrane membrane external side of plasma membrane integral component of membrane platelet alpha granule membrane membrane raft cell surface plasma membrane extracellular space specific granule membrane intracellular anatomical structure receptor complex Biological process low-density lipoprotein particle mediated signaling apoptotic cell clearance positive regulation of MAPK cascade response to lipid nitric oxide mediated signal transduction intestinal absorption positive regulation of blood microparticle formation positive regulation of blood coagulation plasma lipoprotein particle clearance sensory perception of taste blood coagulation cellular response to hydroperoxide positive regulation of ERK1 and ERK2 cascade receptor internalization cellular response to bacterial lipopeptide amyloid fibril formation cellular response to lipopolysaccharide cell surface receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent cholesterol transport platelet degranulation cholesterol import cellular response to diacyl bacterial lipopeptide negative regulation of transcription by RNA polymerase II transport toll-like receptor TLR6:TLR2 signaling pathway phagocytosis, recognition cellular response to low-density lipoprotein particle stimulus positive regulation of macrophage cytokine production immune response response to linoleic acid negative regulation of gene expression positive regulation of reactive oxygen species metabolic process lipoprotein transport positive regulation of cell-matrix adhesion positive regulation of interleukin-12 production triglyceride transport long-chain fatty acid import into cell MyD88-dependent toll-like receptor signaling pathway response to fatty acid regulation of removal of superoxide radicals cellular response to lipoteichoic acid positive regulation of cholesterol storage intestinal cholesterol absorption positive regulation of tumor necrosis factor production receptor-mediated endocytosis lipid metabolism cGMP-mediated signaling positive regulation of phagocytosis, engulfment defense response to Gram-positive bacterium positive regulation of cytosolic calcium ion concentration positive regulation of interleukin-6 production positive regulation of peptidyl-tyrosine phosphorylation positive regulation of I-kappaB kinase/NF-kappaB signaling response to stilbenoid positive regulation of NLRP3 inflammasome complex assembly low-density lipoprotein particle clearance lipid storage positive regulation of macrophage derived foam cell differentiation cell adhesion toll-like receptor signaling pathway neutrophil degranulation regulation of lipid metabolic process production of molecular mediator involved in inflammatory response fatty acid metabolic process phagocytosis, engulfment response to bacterium positive regulation of gene expression positive regulation of cell death cytokine-mediated signaling pathway regulation of lipopolysaccharide-mediated signaling pathway regulation of toll-like receptor signaling pathway negative regulation of protein import into nucleus regulation of protein heterodimerization activity positive regulation of nitric oxide biosynthetic process positive regulation of NF-kappaB transcription factor activity energy homeostasis regulation of action potential positive regulation of cold-induced thermogenesis cellular response to oxidised low-density lipoprotein particle stimulus oxidised low-density lipoprotein particle clearance amyloid-beta clearance by cellular catabolic process positive regulation of reactive oxygen species biosynthetic process cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 948 12491 Ensembl ENSG00000135218 ENSMUSG00000002944 UniProt P16671 Q08857 RefSeq (mRNA) NM_000072 NM_001001547 NM_001001548 NM_001127443 NM_001127444 NM_001289908 NM_001289909 NM_001289911 NM_001371074 NM_001371075 NM_001371077 NM_001371078 NM_001371079 NM_001371080 NM_001371081 NM_001159555 NM_001159556 NM_001159557 NM_001159558 NM_007643 RefSeq (protein) NP_000063 NP_001001547 NP_001001548 NP_001120915 NP_001120916 NP_001276837 NP_001276838 NP_001276840 NP_001358003 NP_001358004 NP_001358006 NP_001358007 NP_001358008 NP_001358009 NP_001358010 NP_001153027 NP_001153028 NP_001153029 NP_001153030 NP_031669 Location (UCSC) Chr 7: 80.37 – 80.68 Mb Chr 5: 17.99 – 18.09 Mb PubMed search [3] [4]
Wikidata
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CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral membrane protein found on the surface of many cell types in vertebrate animals. It imports fatty acids inside cells and is a member of the class B scavenger receptor family of cell surface proteins. CD36 binds many ligands including collagen,^[5] thrombospondin,^[6] erythrocytes parasitized with Plasmodium falciparum,^[7] oxidized low density lipoprotein,^[8][9] native lipoproteins,^[10] oxidized phospholipids,^[11] and long-chain fatty acids.^[12]

Work in genetically modified rodents suggest a role for CD36 in fatty acid metabolism,^[13][14][15] heart disease,^[16] taste,^[17][18][19] and dietary fat processing in the intestine.^[20] It may be involved in glucose intolerance, atherosclerosis, arterial hypertension, diabetes, cardiomyopathy, Alzheimer's disease and various cancers, mostly of epithelial origin (breast, prostate, ovary, and colon) and also for hepatic carcinoma and gliomas.^[21][22][23]