CD38

CD38
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4TMF, 1YH3, 1ZVM, 2EF1, 2HCT, 2I65, 2I66, 2I67, 2O3Q, 2O3R, 2O3S, 2O3T, 2O3U, 2PGJ, 2PGL, 3DZF, 3DZG, 3DZH, 3DZI, 3DZJ, 3DZK, 3F6Y, 3I9M, 3I9N, 3OFS, 3RAJ, 3ROK, 3ROM, 3ROP, 3ROQ, 3U4H, 3U4I, 4CMH, 4F45, 4F46, 4OGW, 4XJS, 4XJT, 5F1K, 5F1O, 5F21
Identifiers
Aliases	CD38, ADPRC1, ADPRC 1, CD38 molecule
External IDs	OMIM: 107270; MGI: 107474; HomoloGene: 1345; GeneCards: CD38; OMA:CD38 - orthologs
EC number	2.4.99.20
Gene location (Human)
Chr.	Chromosome 4 (human)
End	15,853,232 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	44,069,717 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; bone marrow cells; ; lymph node; ; thymus; ; appendix; ; spleen; ; bronchial epithelial cell; ; gonad; ; granulocyte; ; muscle of thigh;
	Top expressed in
	stroma of bone marrow; ; left colon; ; seminal vesicula; ; spleen; ; mesenteric lymph nodes; ; Paneth cell; ; jejunum; ; lumbar subsegment of spinal cord; ; left lung lobe; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; hydrolase activity, acting on glycosyl bonds; NAD(P)+ nucleosidase activity; hydrolase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; NAD+ nucleosidase activity; phosphorus-oxygen lyase activity; identical protein binding;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; cell surface; extracellular exosome; nucleus; plasma membrane; basolateral plasma membrane; secretory granule membrane;
Biological process	B cell receptor signaling pathway; response to cytokine; response to estradiol; response to interleukin-1; response to hypoxia; response to retinoic acid; positive regulation of cytosolic calcium ion concentration; response to progesterone; female pregnancy; negative regulation of apoptotic process; response to hydroperoxide; positive regulation of transcription, DNA-templated; positive regulation of cell growth; positive regulation of B cell proliferation; positive regulation of vasoconstriction; long-term depression; apoptotic signaling pathway; response to hormone; negative regulation of transcription, DNA-templated; signal transduction; positive regulation of insulin secretion; negative regulation of bone resorption; NAD metabolic process; positive regulation of cell population proliferation; negative regulation of neuron projection development; artery smooth muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	952
	12494
	ENSG00000004468
	ENSMUSG00000029084
	P28907
	P56528
	NM_001775
	NM_007646
	NP_001766
	NP_031672
	Wikidata
View/Edit Human	View/Edit Mouse

CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein^[5] found on the surface of many immune cells (white blood cells), including CD4⁺, CD8⁺, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.^[6]

In humans, the CD38 protein is encoded by the CD38 gene which is located on chromosome 4.^[7]^[8] CD38 is a paralog of CD157, which is also located on chromosome 4 (4p15) in humans.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000004468 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029084 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Orciani M, Trubiani O, Guarnieri S, Ferrero E, Di Primio R (October 2008). "CD38 is constitutively expressed in the nucleus of human hematopoietic cells". Journal of Cellular Biochemistry. 105 (3): 905–12. doi:10.1002/jcb.21887. PMID 18759251. S2CID 44430455.
^ "Entrez Gene: CD38 CD38 molecule".
^ Jackson DG, Bell JI (April 1990). "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation". Journal of Immunology. 144 (7): 2811–5. doi:10.4049/jimmunol.144.7.2811. PMID 2319135. S2CID 29082806.
^ Nata K, Takamura T, Karasawa T, Kumagai T, Hashioka W, Tohgo A, et al. (February 1997). "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): 285–92. doi:10.1016/S0378-1119(96)00723-8. PMID 9074508.
^ Quarona V, Zaccarello G, Chillemi A (2013). "CD38 and CD157: a long journey from activation markers to multifunctional molecules". Cytometry Part B. 84 (4): 207–217. doi:10.1002/cyto.b.21092. hdl:2318/134656. PMID 23576305. S2CID 205732787.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000004468 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029084 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18759251-5] Orciani M, Trubiani O, Guarnieri S, Ferrero E, Di Primio R (October 2008). "CD38 is constitutively expressed in the nucleus of human hematopoietic cells". Journal of Cellular Biochemistry. 105 (3): 905–12. doi:10.1002/jcb.21887. PMID 18759251. S2CID 44430455.

[6] "Entrez Gene: CD38 CD38 molecule".

[pmid2319135-7] Jackson DG, Bell JI (April 1990). "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation". Journal of Immunology. 144 (7): 2811–5. doi:10.4049/jimmunol.144.7.2811. PMID 2319135. S2CID 29082806.

[pmid9074508-8] Nata K, Takamura T, Karasawa T, Kumagai T, Hashioka W, Tohgo A, et al. (February 1997). "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): 285–92. doi:10.1016/S0378-1119(96)00723-8. PMID 9074508.

[pmid23576305-9] Quarona V, Zaccarello G, Chillemi A (2013). "CD38 and CD157: a long journey from activation markers to multifunctional molecules". Cytometry Part B. 84 (4): 207–217. doi:10.1002/cyto.b.21092. hdl:2318/134656. PMID 23576305. S2CID 205732787.

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