CD46

CD46
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8
Identifiers
Aliases	CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule
External IDs	OMIM: 120920; MGI: 1203290; HomoloGene: 7832; GeneCards: CD46; OMA:CD46 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	207,795,513 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	194,774,557 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; seminal vesicula; ; bronchial epithelial cell; ; jejunal mucosa; ; germinal epithelium; ; parotid gland; ; placenta; ; right uterine tube; ; right lung; ; body of pancreas;
	Top expressed in
	seminiferous tubule; ; spermatid; ; granulocyte; ; vastus lateralis muscle; ; intestinal villus; ; primary visual cortex; ; lumbar subsegment of spinal cord; ; muscle of thigh; ; ventricular zone; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; cadherin binding; protein binding; complement binding; endopeptidase activity; enzyme inhibitor activity; signaling receptor activity;
Cellular component	integral component of membrane; inner acrosomal membrane; membrane; focal adhesion; plasma membrane; integral component of plasma membrane; cell surface; extracellular exosome; cytoplasmic vesicle; acrosomal vesicle; cytoplasm; Golgi apparatus; basolateral plasma membrane;
Biological process	T cell mediated immunity; adaptive immune response; positive regulation of interleukin-10 production; immune system process; sequestering of extracellular ligand from receptor; positive regulation of regulatory T cell differentiation; negative regulation of gene expression; single fertilization; positive regulation of gene expression; positive regulation of T cell proliferation; positive regulation of memory T cell differentiation; complement activation, classical pathway; positive regulation of transforming growth factor beta production; viral entry into host cell; viral process; regulation of Notch signaling pathway; regulation of complement activation; interleukin-10 production; innate immune response; proteolysis; negative regulation of catalytic activity; negative regulation of complement activation;
	Sources:Amigo / QuickGO
Orthologs
	4179
	17221
	ENSG00000117335
	ENSMUSG00000016493
	P15529
	O88174
NM_002389; NM_153826; NM_172350; NM_172351; NM_172352;
	NM_172353; NM_172354; NM_172355; NM_172356; NM_172357; NM_172358; NM_172359; NM_172360; NM_172361
	NM_010778
NP_002380; NP_722548; NP_758860; NP_758861; NP_758862;
	NP_758863; NP_758869; NP_758871; NP_758865; NP_758866; NP_758867; NP_758868
	NP_034908
	Wikidata
View/Edit Human	View/Edit Mouse

CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene.^[5] CD46 is an inhibitory complement receptor.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117335 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016493 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Taylor CT, Biljan MM, Kingsland CR, Johnson PM (May 1994). "Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein)". Hum. Reprod. 9 (5): 907–11. doi:10.1093/oxfordjournals.humrep.a138615. PMID 7929741.
^ Liszewski MK, Post TW, Atkinson JP (1991). "Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster". Annu. Rev. Immunol. 9 (1): 431–55. doi:10.1146/annurev.iy.09.040191.002243. PMID 1910685.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117335 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016493 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7929741-5] Taylor CT, Biljan MM, Kingsland CR, Johnson PM (May 1994). "Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein)". Hum. Reprod. 9 (5): 907–11. doi:10.1093/oxfordjournals.humrep.a138615. PMID 7929741.

[pmid1910685-6] Liszewski MK, Post TW, Atkinson JP (1991). "Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster". Annu. Rev. Immunol. 9 (1): 431–55. doi:10.1146/annurev.iy.09.040191.002243. PMID 1910685.

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