CD47

CD47
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JJS, 2JJT, 2VSC, 4CMM, 4KJY, 5IWL
Identifiers
Aliases	CD47, IAP, MER6, OA3, CD47 molecule
External IDs	OMIM: 601028; MGI: 96617; HomoloGene: 1346; GeneCards: CD47; OMA:CD47 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.12 Start 108,043,091 bp[1] End 108,091,862 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 49,620,896 bp[2] End 49,735,373 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium palpebral conjunctiva germinal epithelium visceral pleura right uterine tube pancreatic epithelial cell epithelium of nasopharynx Brodmann area 23 tibia pancreatic ductal cell Top expressed in fetal liver hematopoietic progenitor cell tibiofemoral joint blood medial dorsal nucleus cingulate gyrus lateral geniculate nucleus sciatic nerve cerebellar vermis gastrula spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thrombospondin receptor activity protein binding protein binding involved in heterotypic cell-cell adhesion cell-cell adhesion mediator activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane specific granule membrane tertiary granule membrane extracellular exosome cell surface Biological process integrin-mediated signaling pathway positive regulation of phagocytosis cell adhesion extracellular matrix organization positive regulation of inflammatory response positive regulation of T cell activation response to bacterium leukocyte migration positive regulation of cell population proliferation opsonization positive regulation of cell-cell adhesion neutrophil degranulation cell migration regulation of interferon-gamma production regulation of interleukin-10 production regulation of interleukin-12 production regulation of interleukin-6 production regulation of tumor necrosis factor production heterotypic cell-cell adhesion monocyte extravasation regulation of nitric oxide biosynthetic process positive regulation of stress fiber assembly cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-12 cell-cell adhesion negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 961 16423 Ensembl ENSG00000196776 ENSMUSG00000055447 UniProt Q08722 Q61735 RefSeq (mRNA) NM_001025079 NM_001025080 NM_001777 NM_198793 NM_001382306 NM_010581 NM_001368415 NM_001368416 NM_001368417 NM_001368418 RefSeq (protein) NP_001768 NP_942088 NP_001369235 NP_034711 NP_001355344 NP_001355345 NP_001355346 NP_001355347 Location (UCSC) Chr 3: 108.04 – 108.09 Mb Chr 16: 49.62 – 49.74 Mb PubMed search [3] [4]
Wikidata
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CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily^[5] and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).^[6] CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis.^[7]

CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a role in insulin secretion, as well as immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells.^[6][8] Expression in equine cutaneous tumors has been reported as well.^[9]