CD48

CD48
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EDO
Identifiers
Aliases	CD48, BCM1, BLAST, BLAST1, MEM-102, SLAMF2, hmCD48 molecule
External IDs	OMIM: 109530; MGI: 88339; HomoloGene: 1347; GeneCards: CD48; OMA:CD48 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,711,831 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,532,826 bp
RNA expression pattern
	Top expressed in
	white blood cell; ; mononuclear cell; ; monocyte; ; granulocyte; ; blood; ; bone marrow cells; ; appendix; ; spleen; ; lymph node; ; epithelium of colon;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; stroma of bone marrow; ; blood; ; thymus; ; calvaria; ; granulocyte; ; subcutaneous adipose tissue; ; white adipose tissue; ; pharynx;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; antigen binding; signaling receptor activity;
Cellular component	membrane raft; anchored component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; intrinsic component of plasma membrane;
Biological process	defense response; leukocyte migration; regulation of adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	962
	12506
	ENSG00000117091
	ENSMUSG00000015355
	P09326
	P18181
	NM_001256030; NM_001778
	NM_007649; NM_001360767
	NP_001242959; NP_001769
	NP_031675; NP_001347696
	Wikidata
View/Edit Human	View/Edit Mouse

CD48 antigen (Cluster of Differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans is encoded by the CD48 gene.^[5]

CD48 is a member of the CD2 subfamily of the immunoglobulin superfamily (IgSF) which includes SLAM (signaling lymphocyte activation molecules) proteins, such as CD84, CD150, CD229 and CD244. CD48 is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells.^[5]

CD48 was the first B-cell-specific cellular differentiation antigen identified in transformed B lymphoblasts.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117091 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015355 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CD48 CD48 molecule".
^ Thorley-Lawson DA, Schooley RT, Bhan AK, Nadler LM (September 1982). "Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts". Cell. 30 (2): 415–25. doi:10.1016/0092-8674(82)90239-2. PMID 6291768. S2CID 45406805.
^ Yokoyama S, Staunton D, Fisher R, Amiot M, Fortin JJ, Thorley-Lawson DA (April 1991). "Expression of the Blast-1 activation/adhesion molecule and its identification as CD48". J. Immunol. 146 (7): 2192–200. doi:10.4049/jimmunol.146.7.2192. PMID 1848579. S2CID 13131389.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117091 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015355 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD48 CD48 molecule".

[pmid6291768-6] Thorley-Lawson DA, Schooley RT, Bhan AK, Nadler LM (September 1982). "Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts". Cell. 30 (2): 415–25. doi:10.1016/0092-8674(82)90239-2. PMID 6291768. S2CID 45406805.

[pmid1848579-7] Yokoyama S, Staunton D, Fisher R, Amiot M, Fortin JJ, Thorley-Lawson DA (April 1991). "Expression of the Blast-1 activation/adhesion molecule and its identification as CD48". J. Immunol. 146 (7): 2192–200. doi:10.4049/jimmunol.146.7.2192. PMID 1848579. S2CID 13131389.

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