CD52

CD52
Identifiers
Aliases	CD52, CDW52, CD52 molecule, EDDM5, HE5
External IDs	OMIM: 114280; HomoloGene: 88652; GeneCards: CD52; OMA:CD52 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,320,523 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; tail of epididymis; ; granulocyte; ; monocyte; ; spleen; ; thymus; ; right lung; ; lymph node; ; appendix; ; blood;
	n/a
	More reference expression data
	n/a
Orthologs
	1043
	n/a
	ENSG00000169442
	n/a
	P31358
	n/a
	NM_001803
	n/a
	NP_001794
	n/a
	Wikidata
View/Edit Human

CAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the CD52 gene.

CD52 is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found on monocytes^[3] and dendritic cells.^[4] Further, it is found within the male genital tract and is present on the surface of mature sperm cells.

CD52 is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI). Since it is highly negatively charged and present on sperm cells and lymphocytes, it has been conjectured that its function is anti-adhesion, allowing cells to freely move around.^[5]

CD52 binds the ITIM (immunoreceptor tyrosine-based inhibitory motif)-bearing sialic acid-binding lectin SIGLEC10.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169442 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Buggins AG, Mufti GJ, Salisbury J, Codd J, Westwood N, Arno M, Fishlock K, Pagliuca A, Devereux S (September 2002). "Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab". Blood. 100 (5): 1715–20. doi:10.1182/blood.V100.5.1715.h81702001715_1715_1720. PMID 12176892.
^ Ratzinger G, Reagan JL, Heller G, Busam KJ, Young JW (February 2003). "Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation". Blood. 101 (4): 1422–9. doi:10.1182/blood-2002-04-1093. PMID 12393688.
^ Hale G, Waldmann H (2000). "From Laboratory to Clinic : The Story of CAM PA TH-1". Methods Mol. Med. 40: 243–66. doi:10.1385/1-59259-076-4:243. ISBN 978-1-59259-076-6. PMID 21337094.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169442 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12176892-3] Buggins AG, Mufti GJ, Salisbury J, Codd J, Westwood N, Arno M, Fishlock K, Pagliuca A, Devereux S (September 2002). "Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab". Blood. 100 (5): 1715–20. doi:10.1182/blood.V100.5.1715.h81702001715_1715_1720. PMID 12176892.

[pmid12393688-4] Ratzinger G, Reagan JL, Heller G, Busam KJ, Young JW (February 2003). "Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation". Blood. 101 (4): 1422–9. doi:10.1182/blood-2002-04-1093. PMID 12393688.

[pmid21337094-5] Hale G, Waldmann H (2000). "From Laboratory to Clinic : The Story of CAM PA TH-1". Methods Mol. Med. 40: 243–66. doi:10.1385/1-59259-076-4:243. ISBN 978-1-59259-076-6. PMID 21337094.

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