CD8

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Structures	Swiss-model
Domains	InterPro

CD8a molecule
CD8a molecule
Identifiers
Symbol	CD8A
Alt. symbols	CD8
NCBI gene	925
HGNC	1706
OMIM	186910
RefSeq	NM_001768
UniProt	P01732
Other data
Locus	Chr. 2 p12
Structures
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Structures	Swiss-model
Domains	InterPro

Putative T-cell surface glycoprotein CD8
Putative T-cell surface glycoprotein CD8
Identifiers
Symbol	CD8
Membranome	29

CD8b molecule

Identifiers

Symbol

CD8B

Alt. symbols

CD8B1

Other data

Chr. 2 p12

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Structures	Swiss-model
Domains	InterPro

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.

Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the MHC class I protein.^[1]

There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12.

^ Gao G, Jakobsen B (2000). "Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor". Immunol Today. 21 (12): 630–6. doi:10.1016/S0167-5699(00)01750-3. PMID 11114424.

[1] Gao G, Jakobsen B (2000). "Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor". Immunol Today. 21 (12): 630–6. doi:10.1016/S0167-5699(00)01750-3. PMID 11114424.

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