CD81

CD81
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G8Q, 1IV5, 3X0E, 5DFW, 5DFV
Identifiers
Aliases	CD81, CVID6, S5.7, TAPA1, TSPAN28, CD81 molecule
External IDs	OMIM: 186845; MGI: 1096398; HomoloGene: 20915; GeneCards: CD81; OMA:CD81 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 2,376,177 bp[1] End 2,397,397 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 88.1 cM Start 142,606,476 bp[2] End 142,621,671 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium seminal vesicula body of uterus right coronary artery canal of the cervix right uterine tube Descending thoracic aorta left uterine tube ascending aorta apex of heart Top expressed in aortic valve ascending aorta anterior horn of spinal cord Epithelium of choroid plexus efferent ductule dentate gyrus of hippocampal formation granule cell molar optic nerve external carotid artery choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding MHC class II protein complex binding transferrin receptor binding virus receptor activity integrin binding cholesterol binding lipid binding Cellular component integral component of membrane vesicle membrane focal adhesion integral component of plasma membrane immunological synapse extracellular exosome plasma membrane basolateral plasma membrane Biological process positive regulation of 1-phosphatidylinositol 4-kinase activity protein localization regulation of protein stability receptor internalization cellular response to low-density lipoprotein particle stimulus regulation of cell motility receptor-mediated virion attachment to host cell protein localization to lysosome cell surface receptor signaling pathway positive regulation of B cell proliferation positive regulation of cell population proliferation regulation of immune response positive regulation of peptidyl-tyrosine phosphorylation viral entry into host cell positive regulation of protein catabolic process in the vacuole cell population proliferation viral process positive regulation of transcription by RNA polymerase II regulation of complement activation humoral immune response mediated by circulating immunoglobulin protein localization to plasma membrane adaptive immune response immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 975 12520 Ensembl ENSG00000110651 ENSMUSG00000037706 UniProt P60033 P35762 RefSeq (mRNA) NM_001297649 NM_004356 NM_133655 RefSeq (protein) NP_001284578 NP_004347 NP_598416 Location (UCSC) Chr 11: 2.38 – 2.4 Mb Chr 7: 142.61 – 142.62 Mb PubMed search [3] [4]
Wikidata
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CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene.^[5][6] It is also known as 26 kDa cell surface protein, TAPA-1 (Target of the Antiproliferative Antibody 1), and Tetraspanin-28 (Tspan-28).