CD86

CD86
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I85, 1NCN
Identifiers
Aliases	CD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule
External IDs	OMIM: 601020; MGI: 101773; HomoloGene: 10443; GeneCards: CD86; OMA:CD86 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.33 Start 122,055,362 bp[1] End 122,121,139 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B3|16 25.72 cM Start 36,424,231 bp[2] End 36,486,443 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte appendix testicle blood lymph node gallbladder spleen right lung rectum Top expressed in spleen lumbar spinal ganglion granulocyte mesenteric lymph nodes thymus stroma of bone marrow blood subcutaneous adipose tissue Paneth cell lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function coreceptor activity virus receptor activity protein binding signaling receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity signaling receptor activity Cellular component integral component of membrane intracellular membrane-bounded organelle membrane plasma membrane cell surface extracellular exosome external side of plasma membrane Biological process response to yeast adaptive immune response response to interferon-gamma immune system process cell-cell signaling T cell costimulation human ageing myeloid dendritic cell differentiation cellular response to cytokine stimulus T cell proliferation involved in immune response toll-like receptor signaling pathway positive regulation of transcription, DNA-templated B cell activation response to lipopolysaccharide cellular response to metal ion negative regulation of T cell anergy defense response to virus immune response positive regulation of T cell proliferation positive regulation of cell population proliferation positive regulation of T-helper 2 cell differentiation viral entry into host cell viral process toll-like receptor 3 signaling pathway cellular response to lipopolysaccharide T cell activation positive regulation of activated T cell proliferation phosphatidylinositol phosphate biosynthetic process positive regulation of protein kinase B signaling signal transduction cell surface receptor signaling pathway cytokine-mediated signaling pathway negative regulation of T cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 942 12524 Ensembl ENSG00000114013 ENSMUSG00000022901 UniProt P42081 P42082 RefSeq (mRNA) NM_176892 NM_001206924 NM_001206925 NM_006889 NM_175862 NM_019388 RefSeq (protein) NP_001193853 NP_001193854 NP_008820 NP_787058 NP_795711 NP_062261 Location (UCSC) Chr 3: 122.06 – 122.12 Mb Chr 16: 36.42 – 36.49 Mb PubMed search [3] [4]
Wikidata
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Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on other antigen-presenting cells.^[5] Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival. Depending on the ligand bound, CD86 can signal for self-regulation and cell-cell association, or for attenuation of regulation and cell-cell disassociation.^[6]

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.^[7] Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.^[8]