CD9

CD9
Identifiers
Aliases	CD9, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29, CD9 molecule
External IDs	OMIM: 143030; MGI: 88348; HomoloGene: 20420; GeneCards: CD9; OMA:CD9 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,238,271 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	125,471,754 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; seminal vesicula; ; mucosa of sigmoid colon; ; trigeminal ganglion; ; Achilles tendon; ; synovial joint; ; urethra; ; bronchial epithelial cell; ; oral cavity; ; mucosa of nose;
	Top expressed in
	skin of external ear; ; right lung lobe; ; seminal vesicula; ; transitional epithelium of urinary bladder; ; left lung; ; granulocyte; ; parotid gland; ; lip; ; left lung lobe; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding; protein binding;
Cellular component	integral component of membrane; external side of plasma membrane; endocytic vesicle membrane; membrane; cell surface; plasma membrane; clathrin-coated endocytic vesicle membrane; focal adhesion; extracellular vesicle; platelet alpha granule membrane; apical plasma membrane; extracellular exosome; extracellular space; integral component of plasma membrane; extracellular region;
Biological process	negative regulation of cell population proliferation; paranodal junction assembly; platelet degranulation; cell surface receptor signaling pathway; response to water deprivation; oligodendrocyte development; receptor internalization; fusion of sperm to egg plasma membrane involved in single fertilization; cell adhesion; brain development; cellular response to low-density lipoprotein particle stimulus; single fertilization; platelet activation; negative regulation of platelet aggregation; sperm-egg recognition; myoblast fusion involved in skeletal muscle regeneration; regulation of macrophage migration;
	Sources:Amigo / QuickGO
Orthologs
	928
	12527
	ENSG00000010278
	ENSMUSG00000030342
	P21926
	P40240
	NM_001769; NM_001330312
	NM_007657
	NP_001317241; NP_001760
	NP_031683
	Wikidata
View/Edit Human	View/Edit Mouse

CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family.^[5]^[6]^[7] Also containing distinct palmitoylation sites that allows CD9 to interact with lipids and other proteins.^[5]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000010278 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030342 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Andreu Z, Yáñez-Mó M (2014). "Tetraspanins in extracellular vesicle formation and function". Frontiers in Immunology. 8: 342. doi:10.3389/fimmu.2014.00442. PMC 4165315. PMID 25278937.
^ "CD9 CD9 molecule [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-12-04.
^ "CD9 Gene - GeneCards | CD9 Protein | CD9 Antibody". www.genecards.org. Retrieved 2019-12-04.
^ Yáñez-Mó M, Barreiro O, Gordon-Alonso M, Sala-Valdés M, Sánchez-Madrid F (September 2009). "Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes". Trends in Cell Biology. 19 (9): 434–46. doi:10.1016/j.tcb.2009.06.004. PMID 19709882.
^ Yang XH, Kovalenko OV, Kolesnikova TV, Andzelm MM, Rubinstein E, Strominger JL, Hemler ME (May 2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". The Journal of Biological Chemistry. 281 (18): 12976–85. doi:10.1074/jbc.M510617200. PMID 16537545.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000010278 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030342 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Andreu_2014-5] Andreu Z, Yáñez-Mó M (2014). "Tetraspanins in extracellular vesicle formation and function". Frontiers in Immunology. 8: 342. doi:10.3389/fimmu.2014.00442. PMC 4165315. PMID 25278937.

[6] "CD9 CD9 molecule [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-12-04.

[7] "CD9 Gene - GeneCards | CD9 Protein | CD9 Antibody". www.genecards.org. Retrieved 2019-12-04.

[Yáñez-Mó_2009-8] Yáñez-Mó M, Barreiro O, Gordon-Alonso M, Sala-Valdés M, Sánchez-Madrid F (September 2009). "Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes". Trends in Cell Biology. 19 (9): 434–46. doi:10.1016/j.tcb.2009.06.004. PMID 19709882.

[Yang_2006-9] Yang XH, Kovalenko OV, Kolesnikova TV, Andzelm MM, Rubinstein E, Strominger JL, Hemler ME (May 2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". The Journal of Biological Chemistry. 281 (18): 12976–85. doi:10.1074/jbc.M510617200. PMID 16537545.

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