CD97

ADGRE5
Identifiers
Aliases	ADGRE5, TM7LN1, CD97, adhesion G protein-coupled receptor E5
External IDs	OMIM: 601211; MGI: 1347095; HomoloGene: 8050; GeneCards: ADGRE5; OMA:ADGRE5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,408,725 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,467,955 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; ascending aorta; ; blood; ; Descending thoracic aorta; ; body of uterus; ; spleen; ; right coronary artery; ; upper lobe of left lung; ; stromal cell of endometrium;
	Top expressed in
	granulocyte; ; thymus; ; urinary bladder; ; esophagus; ; proximal tubule; ; lung; ; jejunum; ; smooth muscle tissue; ; spleen; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; protein binding; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; focal adhesion; extracellular space; secretory granule membrane;
Biological process	cell-cell signaling; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cell adhesion; inflammatory response; immune response; signal transduction; neutrophil degranulation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	976
	26364
	ENSG00000123146
	ENSMUSG00000002885
	P48960
	Q9Z0M6
	NM_001025160; NM_001784; NM_078481
	NM_001163029; NM_001163030; NM_001163031; NM_011925
	NP_001020331; NP_001775; NP_510966
	NP_001156501; NP_001156502; NP_001156503; NP_036055
	Wikidata
View/Edit Human	View/Edit Mouse

Cluster of differentiation 97 is a protein also known as BL-Ac[F2] encoded by the ADGRE5 gene.^[5]^[6]^[7]^[8] CD97 is a member of the adhesion G protein-coupled receptor (GPCR) family.^[9]^[10] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[11]

CD97 is widely expressed on, among others, hematopoietic stem and progenitor cells, immune cells, epithelial cells, muscle cells as well as their malignant counterparts.^[12]^[13]^[14]^[15]^[16]^[17] In the case of CD97 the N-terminal domains consist of alternatively spliced epidermal growth factor (EGF)-like domains. Alternative splicing has been observed for this gene and three variants have been found.^[7] The N-terminal fragment of CD97 contains 3-5 EGF-like domains in human and 3-4 EGF-like domains in mice.^[18]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123146 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002885 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hamann J, Eichler W, Hamann D, Kerstens HM, Poddighe PJ, Hoovers JM, Hartmann E, Strauss M, van Lier RA (Aug 1995). "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain". Journal of Immunology. 155 (4): 1942–50. doi:10.4049/jimmunol.155.4.1942. PMID 7636245. S2CID 10538838.
^ Hamann J, Hartmann E, van Lier RA (Feb 1996). "Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily". Genomics. 32 (1): 144–7. doi:10.1006/geno.1996.0092. PMID 8786105.
^ ^a ^b "Entrez Gene: CD97 CD97 molecule".
^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
^ van Pel M, Hagoort H, Hamann J, Fibbe WE (Aug 2008). "CD97 is differentially expressed on murine hematopoietic stem-and progenitor-cells". Haematologica. 93 (8): 1137–44. doi:10.3324/haematol.12838. PMID 18603564.
^ Eichler W, Hamann J, Aust G (Nov 1997). "Expression characteristics of the human CD97 antigen". Tissue Antigens. 50 (5): 429–38. doi:10.1111/j.1399-0039.1997.tb02897.x. PMID 9389316.
^ Jaspars LH, Vos W, Aust G, Van Lier RA, Hamann J (Apr 2001). "Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens. 57 (4): 325–31. doi:10.1034/j.1399-0039.2001.057004325.x. PMID 11380941.
^ Aust G, Wandel E, Boltze C, Sittig D, Schütz A, Horn LC, Wobus M (Apr 2006). "Diversity of CD97 in smooth muscle cells". Cell and Tissue Research. 324 (1): 139–47. doi:10.1007/s00441-005-0103-2. PMID 16408199. S2CID 36161414.
^ Veninga H, Becker S, Hoek RM, Wobus M, Wandel E, van der Kaa J, van der Valk M, de Vos AF, Haase H, Owens B, van der Poll T, van Lier RA, Verbeek JS, Aust G, Hamann J (Nov 2008). "Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration". Journal of Immunology. 181 (9): 6574–83. doi:10.4049/jimmunol.181.9.6574. PMID 18941248.
^ Zyryanova T, Schneider R, Adams V, Sittig D, Kerner C, Gebhardt C, Ruffert H, Glasmacher S, Hepp P, Punkt K, Neuhaus J, Hamann J, Aust G (2014). "Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function". PLOS ONE. 9 (6): e100513. Bibcode:2014PLoSO...9j0513Z. doi:10.1371/journal.pone.0100513. PMC 4065095. PMID 24949957.
^ Gordon S, Hamann J, Lin HH, Stacey M (Sep 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology. 41 (9): 2472–6. doi:10.1002/eji.201141715. PMID 21952799.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123146 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002885 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7636245-5] Hamann J, Eichler W, Hamann D, Kerstens HM, Poddighe PJ, Hoovers JM, Hartmann E, Strauss M, van Lier RA (Aug 1995). "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain". Journal of Immunology. 155 (4): 1942–50. doi:10.4049/jimmunol.155.4.1942. PMID 7636245. S2CID 10538838.

[pmid8786105-6] Hamann J, Hartmann E, van Lier RA (Feb 1996). "Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily". Genomics. 32 (1): 144–7. doi:10.1006/geno.1996.0092. PMID 8786105.

[entrez-7] "Entrez Gene: CD97 CD97 molecule".

[8] Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[isbn1-4419-7912-3-9] Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[10] Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.

[pmid22333914-11] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[12] van Pel M, Hagoort H, Hamann J, Fibbe WE (Aug 2008). "CD97 is differentially expressed on murine hematopoietic stem-and progenitor-cells". Haematologica. 93 (8): 1137–44. doi:10.3324/haematol.12838. PMID 18603564.

[13] Eichler W, Hamann J, Aust G (Nov 1997). "Expression characteristics of the human CD97 antigen". Tissue Antigens. 50 (5): 429–38. doi:10.1111/j.1399-0039.1997.tb02897.x. PMID 9389316.

[14] Jaspars LH, Vos W, Aust G, Van Lier RA, Hamann J (Apr 2001). "Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens. 57 (4): 325–31. doi:10.1034/j.1399-0039.2001.057004325.x. PMID 11380941.

[15] Aust G, Wandel E, Boltze C, Sittig D, Schütz A, Horn LC, Wobus M (Apr 2006). "Diversity of CD97 in smooth muscle cells". Cell and Tissue Research. 324 (1): 139–47. doi:10.1007/s00441-005-0103-2. PMID 16408199. S2CID 36161414.

[16] Veninga H, Becker S, Hoek RM, Wobus M, Wandel E, van der Kaa J, van der Valk M, de Vos AF, Haase H, Owens B, van der Poll T, van Lier RA, Verbeek JS, Aust G, Hamann J (Nov 2008). "Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration". Journal of Immunology. 181 (9): 6574–83. doi:10.4049/jimmunol.181.9.6574. PMID 18941248.

[ReferenceA-17] Zyryanova T, Schneider R, Adams V, Sittig D, Kerner C, Gebhardt C, Ruffert H, Glasmacher S, Hepp P, Punkt K, Neuhaus J, Hamann J, Aust G (2014). "Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function". PLOS ONE. 9 (6): e100513. Bibcode:2014PLoSO...9j0513Z. doi:10.1371/journal.pone.0100513. PMC 4065095. PMID 24949957.

[18] Gordon S, Hamann J, Lin HH, Stacey M (Sep 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology. 41 (9): 2472–6. doi:10.1002/eji.201141715. PMID 21952799.

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