| CLEC10A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CLEC10A, CD301, CLECSF13, CLECSF14, HML, HML2, MGL, C-type lectin domain family 10 member A, C-type lectin domain containing 10A | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605999; MGI: 96975; HomoloGene: 7836; GeneCards: CLEC10A; OMA:CLEC10A - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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C-type lectin domain family 10 member A (CLEC10A) also designated as CD301 is a protein that in humans is encoded by the CLEC10A gene.[5] CLEC10A is part of the C-type lectin superfamily and binds to N-Acetylgalactosamine (GalNAc). It is mainly expressed on myeloid cells and also on oocytes and very early stages of embryogenesis. CLEC10A is used as a marker of the CD1c+ dendritic cell subgroup, also called cDC2.[6] The actions of CLEC10A are diverse, depending on the ligand and environment.[7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000132514 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000318 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Suzuki N, Yamamoto K, Toyoshima S, Osawa T, Irimura T (January 1996). "Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen". Journal of Immunology. 156 (1): 128–135. doi:10.4049/jimmunol.156.1.128. PMID 8598452. S2CID 25597354.
- ^ Heger L, Balk S, Lühr JJ, Heidkamp GF, Lehmann CH, Hatscher L, et al. (2018-04-27). "CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion". Frontiers in Immunology. 9: 744. doi:10.3389/fimmu.2018.00744. PMC 5934495. PMID 29755453.
- ^ Hoober JK (July 2020). "ASGR1 and Its Enigmatic Relative, CLEC10A". International Journal of Molecular Sciences. 21 (14): 4818. doi:10.3390/ijms21144818. PMC 7404283. PMID 32650396.
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