CLEC7A

CLEC7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BPD, 2BPE, 2BPH, 2CL8
Identifiers
Aliases	CLEC7A, BGR, CANDF4, CLECSF12, DECTIN1, CD369, SCARE2, C-type lectin domain family 7 member A, C-type lectin domain containing 7A
External IDs	OMIM: 606264; MGI: 1861431; HomoloGene: 49606; GeneCards: CLEC7A; OMA:CLEC7A - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 10,116,777 bp[1] End 10,130,258 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F3 Start 129,438,554 bp[2] End 129,449,742 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood buccal mucosa cell periodontal fiber tendon of biceps brachii right lung appendix spleen upper lobe of left lung Top expressed in granulocyte right lung lobe blood mesenteric lymph nodes tibiofemoral joint bone marrow left lung mucous cell of stomach subcutaneous adipose tissue spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MHC protein binding pattern recognition receptor activity metal ion binding protein binding carbohydrate binding Cellular component cytoplasm integral component of membrane intracellular membrane-bounded organelle membrane plasma membrane nucleoplasm Biological process cell recognition immune system process carbohydrate mediated signaling phagocytosis, recognition inflammatory response T cell activation defense response to protozoan pattern recognition receptor signaling pathway innate immune response positive regulation of protein-containing complex assembly positive regulation of interleukin-1 beta production positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of phagocytosis positive regulation of killing of cells of other organism positive regulation of cytokine production involved in inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64581 56644 Ensembl ENSG00000172243 ENSMUSG00000079293 UniProt Q9BXN2 V9GXI5 RefSeq (mRNA) NM_022570 NM_197947 NM_197948 NM_197949 NM_197950 NM_197951 NM_197952 NM_197953 NM_197954 NM_020008 NM_001309637 RefSeq (protein) NP_072092 NP_922938 NP_922939 NP_922940 NP_922941 NP_922945 NP_001296566 NP_064392 Location (UCSC) Chr 12: 10.12 – 10.13 Mb Chr 6: 129.44 – 129.45 Mb PubMed search [3] [4]
Wikidata
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C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene.^[5] CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor for a variety of β-1,3-linked and β-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Expression is found on myeloid dendritic cells, monocytes, macrophages and B cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[5]