CXCR4

CXCR4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RWS, 2K03, 2K04, 2K05, 3ODU, 3OE0, 3OE6, 3OE8, 3OE9, 2N55
Identifiers
Aliases	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, C-X-C motif chemokine receptor 4, WHIMS1
External IDs	OMIM: 162643; MGI: 109563; HomoloGene: 20739; GeneCards: CXCR4; OMA:CXCR4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	136,119,177 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	128,520,030 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; thymus; ; epithelium of nasopharynx; ; lymph node; ; appendix; ; bone marrow cells; ; blood; ; spleen; ; visceral pleura; ; trabecular bone;
	Top expressed in
	granulocyte; ; thymus; ; tibiofemoral joint; ; spleen; ; stroma of bone marrow; ; mesenteric lymph nodes; ; blood; ; aortic valve; ; lumbar spinal ganglion; ; right lung lobe;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytokine binding; coreceptor activity; virus receptor activity; signal transducer activity; protein binding; chemokine receptor activity; myosin light chain binding; actin binding; ubiquitin protein ligase binding; G protein-coupled receptor activity; C-X-C chemokine receptor activity; ubiquitin binding; C-C chemokine binding; C-C chemokine receptor activity; chemokine binding; C-X-C motif chemokine 12 receptor activity;
Cellular component	cytoplasm; integral component of membrane; endosome; membrane; cell surface; cell junction; cell leading edge; extracellular exosome; cytoplasmic vesicle; early endosome; late endosome; lysosome; plasma membrane; external side of plasma membrane; protein-containing complex; nucleus;
Biological process	myelin maintenance; positive regulation of oligodendrocyte differentiation; response to hypoxia; positive regulation of cytosolic calcium ion concentration; chemokine-mediated signaling pathway; response to virus; dendritic cell chemotaxis; cellular response to cytokine stimulus; chemotaxis; inflammatory response; calcium-mediated signaling; signal transduction; apoptotic process; viral process; fusion of virus membrane with host plasma membrane; regulation of chemotaxis; G protein-coupled receptor signaling pathway; axon guidance; immune response; brain development; neurogenesis; CXCL12-activated CXCR4 signaling pathway; cell chemotaxis; positive regulation of cold-induced thermogenesis; regulation of cell adhesion; neuron migration; epithelial cell development; neuron recognition; response to activity; cell migration; telencephalon cell migration; positive regulation of cell migration; positive regulation of vascular wound healing; regulation of programmed cell death; response to morphine; endothelial cell differentiation; positive regulation of neurogenesis; regulation of viral process; positive regulation of chemotaxis; detection of temperature stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of pain; regulation of calcium ion transport; cardiac muscle contraction; endothelial tube morphogenesis; positive regulation of dendrite extension; positive regulation of mesenchymal stem cell migration; response to ultrasound;
	Sources:Amigo / QuickGO
Orthologs
	7852
	12767
	ENSG00000121966
	ENSMUSG00000045382
	P61073
	P70658
	NM_003467; NM_001008540; NM_001348056; NM_001348059; NM_001348060
	NM_009911; NM_001356509
	NP_001008540; NP_003458; NP_001334985; NP_001334988; NP_001334989
	NP_034041; NP_001343438
	Wikidata
View/Edit Human	View/Edit Mouse

C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene.^[5]^[6] The protein is a CXC chemokine receptor.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121966 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045382 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moriuchi M, Moriuchi H, Turner W, Fauci AS (November 1997). "Cloning and analysis of The sigma gene the promoter region of CXCR4, a coreceptor for HIV-1 entry". Journal of Immunology. 159 (9): 4322–9. doi:10.4049/jimmunol.159.9.4322. PMID 9379028. S2CID 36552134.
^ Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (April 1998). "Genomic organization and promoter characterization of human CXCR4 gene". FEBS Letters. 426 (2): 271–8. doi:10.1016/S0014-5793(98)00359-7. PMID 9599023. S2CID 36571818.
^ "Gene group: C-X-C motif chemokine receptors (CXCR)". HUGO Gene Nomenclature Committee.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121966 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045382 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9379028-5] Moriuchi M, Moriuchi H, Turner W, Fauci AS (November 1997). "Cloning and analysis of The sigma gene the promoter region of CXCR4, a coreceptor for HIV-1 entry". Journal of Immunology. 159 (9): 4322–9. doi:10.4049/jimmunol.159.9.4322. PMID 9379028. S2CID 36552134.

[pmid9599023-6] Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (April 1998). "Genomic organization and promoter characterization of human CXCR4 gene". FEBS Letters. 426 (2): 271–8. doi:10.1016/S0014-5793(98)00359-7. PMID 9599023. S2CID 36571818.

[7] "Gene group: C-X-C motif chemokine receptors (CXCR)". HUGO Gene Nomenclature Committee.

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