Cadherin-1

CDH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O6S, 2O72, 2OMT, 2OMU, 2OMV, 2OMX, 2OMY, 2OMZ, 3FF7, 3FF8, 3L6X, 3L6Y, 4ZT1, 4ZTE
Identifiers
Aliases	CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, BCDS1, E-cadherin, uvomorulin
External IDs	OMIM: 192090; MGI: 88354; HomoloGene: 20917; GeneCards: CDH1; OMA:CDH1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 68,737,292 bp[1] End 68,835,537 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.18 cM Start 107,329,983 bp[2] End 107,396,878 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa gingival epithelium mucosa of sigmoid colon skin of thigh palpebral conjunctiva skin of hip bronchial epithelial cell duodenum mucosa of ileum epithelium of nasopharynx Top expressed in epithelium of stomach left colon transitional epithelium of urinary bladder epithelium of small intestine stria vascularis migratory enteric neural crest cell mucous cell of stomach submandibular gland pyloric antrum left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding ankyrin binding gamma-catenin binding beta-catenin binding GTPase activating protein binding metal ion binding cell adhesion molecule binding cadherin binding identical protein binding cytoskeletal protein binding protein homodimerization activity Cellular component apical junction complex trans-Golgi network extracellular region perinuclear region of cytoplasm cortical actin cytoskeleton Golgi apparatus lamellipodium cytoplasmic side of plasma membrane endosome lateral plasma membrane catenin complex actin cytoskeleton flotillin complex membrane extracellular exosome integral component of membrane cell junction cytoplasm plasma membrane cell surface postsynapse glutamatergic synapse Biological process negative regulation of cell-cell adhesion positive regulation of transcription, DNA-templated cellular response to lithium ion cell adhesion extracellular matrix organization cellular response to indole-3-methanol extracellular matrix disassembly synapse assembly pituitary gland development response to toxic substance response to organic substance neuron projection development adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules entry of bacterium into host cell protein localization to plasma membrane cell-cell adhesion cell morphogenesis cell-cell junction assembly regulation of gene expression calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules negative regulation of cell migration positive regulation of protein import into nucleus cell-cell adhesion mediated by cadherin regulation of protein catabolic process at postsynapse, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 999 12550 Ensembl ENSG00000039068 ENSMUSG00000000303 UniProt P12830 P09803 RefSeq (mRNA) NM_004360 NM_001317184 NM_001317185 NM_001317186 NM_009864 RefSeq (protein) NP_001304113 NP_001304114 NP_001304115 NP_004351 NP_033994 Location (UCSC) Chr 16: 68.74 – 68.84 Mb Chr 8: 107.33 – 107.4 Mb PubMed search [3] [4]
Wikidata
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Cadherin-1 or Epithelial cadherin (E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the CDH1 gene.^[5] Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene.^[6][7]