Cadherin-2

CDH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NCG, 1NCH, 1NCI, 1NCJ, 1OP4, 2QVI, 3Q2W, 4NUM, 4NUP, 4NUQ
Identifiers
Aliases	CDH2, CD325, CDHN, CDw325, NCAD, cadherin 2, ACOGS, ARVD14
External IDs	OMIM: 114020; MGI: 88355; HomoloGene: 20424; GeneCards: CDH2; OMA:CDH2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.1 Start 27,932,879 bp[1] End 28,177,946 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 A1|18 10.1 cM Start 16,721,934 bp[2] End 16,942,303 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle ventricular zone stromal cell of endometrium myocardium myocardium of left ventricle endothelial cell ganglionic eminence cardiac muscle tissue of right atrium Brodmann area 23 middle temporal gyrus Top expressed in median eminence atrium lateral septal nucleus myocardium of ventricle ventromedial nucleus lateral geniculate nucleus cardiac muscle tissue of left ventricle dorsomedial hypothalamic nucleus mammillary body arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding gamma-catenin binding metal ion binding protein binding enzyme binding protein phosphatase binding alpha-catenin binding protein kinase binding beta-catenin binding identical protein binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component cytoplasm integral component of membrane membrane intercalated disc cell-cell junction focal adhesion plasma membrane raft adherens junction plasma membrane synapse basolateral plasma membrane apical plasma membrane cortical actin cytoskeleton catenin complex fascia adherens extracellular exosome lamellipodium postsynaptic density sarcolemma endoplasmic reticulum lumen cell surface cell junction extracellular matrix integral component of plasma membrane neuron projection apical part of cell collagen-containing extracellular matrix integral component of presynaptic active zone membrane integral component of postsynaptic specialization membrane Biological process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules blood vessel morphogenesis homeostasis of number of cells positive regulation of muscle cell differentiation regulation of postsynaptic density protein 95 clustering glial cell differentiation neuroepithelial cell differentiation cell-cell adhesion mediated by cadherin radial glial cell differentiation neuronal stem cell population maintenance regulation of oligodendrocyte progenitor proliferation telencephalon development neuroligin clustering involved in postsynaptic membrane assembly positive regulation of synaptic vesicle clustering cell adhesion regulation of signal transduction cerebral cortex development striated muscle cell differentiation adherens junction organization cell migration negative regulation of canonical Wnt signaling pathway positive regulation of MAPK cascade homophilic cell adhesion via plasma membrane adhesion molecules brain morphogenesis post-translational protein modification protein localization to plasma membrane cell morphogenesis cell-cell junction assembly synapse assembly regulation of axonogenesis regulation of synaptic transmission, glutamatergic cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1000 12558 Ensembl ENSG00000170558 ENSMUSG00000024304 UniProt P19022 P15116 RefSeq (mRNA) NM_001308176 NM_001792 NM_007664 RefSeq (protein) NP_001295105 NP_001783 NP_001783.2 NP_031690 Location (UCSC) Chr 18: 27.93 – 28.18 Mb Chr 18: 16.72 – 16.94 Mb PubMed search [3] [4]
Wikidata
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Cadherin-2 also known as Neural cadherin (N-cadherin), is a protein that in humans is encoded by the CDH2 gene.^[5][6][7] CDH2 has also been designated as CD325 (cluster of differentiation 325). Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human dilated cardiomyopathy. Variants in CDH2 have also been identified to cause a syndromic neurodevelopmental disorder.^[8]