Cefotiam

Cefotiam
Clinical data
Trade names	Pansporin
AHFS/Drugs.com	International Drug Names
Routes of; administration	Intravenous, intramuscular
ATC code	J01DC07 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	60% (intramuscular)
Protein binding	40%
Metabolism	Nil
Elimination half-life	Approximately 1 hour
Excretion	Renal
Identifiers
	IUPAC name (6R,7R)-7-{[2-(2-amino-1,3-thiazol-4-yl)acetyl]; amino}-3-{[1-(2-dimethylaminoethyl)tetrazol-5-yl]; sulfanylmethyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]; oct-2-ene-2-carboxylic acid;
CAS Number	61622-34-2 ;
PubChem CID	43708;
DrugBank	DB00229 ;
ChemSpider	39831 ;
UNII	91W6Z2N718;
KEGG	D07648 ;
ChEBI	CHEBI:355510 ;
ChEMBL	ChEMBL1296 ;
CompTox Dashboard (EPA)	DTXSID6022763 ;
ECHA InfoCard	100.205.922
Chemical and physical data
Formula	C18H23N9O4S3
Molar mass	525.62 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCN1N=NN=C1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)CC1=CSC(N)=N1)C2=O)C(O)=O;
	InChI InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1 ; Key:QYQDKDWGWDOFFU-IUODEOHRSA-N ;
	(verify)

Cefotiam is a parenteral third-generation cephalosporin antibiotic. It has broad-spectrum activity against Gram-positive and Gram-negative bacteria. As a beta-lactam, its bactericidal activity results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins.

It was patented in 1973 and approved for medical use in 1981.^[1]

^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 494. ISBN 978-3-527-60749-5.